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Open Access
Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders
F.V. Brozovich, C.J. Nicholson, C.V. Degen, Yuan Z. Gao, M. Aggarwal and K.G. Morgan
Stephanie W. Watts, ASSOCIATE EDITOR
Pharmacological Reviews April 2016, 68 (2) 476-532; DOI: https://doi.org/10.1124/pr.115.010652
F.V. Brozovich
Department of Health Sciences, Boston University, Boston, Massachusetts (C.J.N., Y.Z.G., M.A., K.G.M.); Department of Medicine, Mayo Clinic, Rochester, Minnesota (F.V.B.); and Paracelsus Medical University Salzburg, Salzburg, Austria (C.V.D.)
C.J. Nicholson
Department of Health Sciences, Boston University, Boston, Massachusetts (C.J.N., Y.Z.G., M.A., K.G.M.); Department of Medicine, Mayo Clinic, Rochester, Minnesota (F.V.B.); and Paracelsus Medical University Salzburg, Salzburg, Austria (C.V.D.)
C.V. Degen
Department of Health Sciences, Boston University, Boston, Massachusetts (C.J.N., Y.Z.G., M.A., K.G.M.); Department of Medicine, Mayo Clinic, Rochester, Minnesota (F.V.B.); and Paracelsus Medical University Salzburg, Salzburg, Austria (C.V.D.)
Yuan Z. Gao
Department of Health Sciences, Boston University, Boston, Massachusetts (C.J.N., Y.Z.G., M.A., K.G.M.); Department of Medicine, Mayo Clinic, Rochester, Minnesota (F.V.B.); and Paracelsus Medical University Salzburg, Salzburg, Austria (C.V.D.)
M. Aggarwal
Department of Health Sciences, Boston University, Boston, Massachusetts (C.J.N., Y.Z.G., M.A., K.G.M.); Department of Medicine, Mayo Clinic, Rochester, Minnesota (F.V.B.); and Paracelsus Medical University Salzburg, Salzburg, Austria (C.V.D.)
K.G. Morgan
Department of Health Sciences, Boston University, Boston, Massachusetts (C.J.N., Y.Z.G., M.A., K.G.M.); Department of Medicine, Mayo Clinic, Rochester, Minnesota (F.V.B.); and Paracelsus Medical University Salzburg, Salzburg, Austria (C.V.D.)
Stephanie W. Watts
Department of Health Sciences, Boston University, Boston, Massachusetts (C.J.N., Y.Z.G., M.A., K.G.M.); Department of Medicine, Mayo Clinic, Rochester, Minnesota (F.V.B.); and Paracelsus Medical University Salzburg, Salzburg, Austria (C.V.D.)
Roles: ASSOCIATE EDITOR

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In this issue
Review ArticleReview Article
Mechanisms of Vascular Smooth Muscle Contraction
F.V. Brozovich, C.J. Nicholson, C.V. Degen, Yuan Z. Gao, M. Aggarwal and K.G. Morgan
Pharmacological Reviews April 1, 2016, 68 (2) 476-532; DOI: https://doi.org/10.1124/pr.115.010652
Jump to section
- Article
- Abstract
- I. Introduction
- II. Regulation of Ca2+
- III. Vascular Smooth Muscle Signal Transduction
- IV. Regulation of Smooth Muscle Myosin
- V. Cytoskeletal Regulation
- VI. Identifying Therapeutic Targets in Vascular Smooth Muscle through Biomechanical Studies
- VII. Regulation of Vascular Smooth Muscle Cell Function by Epigenetic Mechanisms
- VIII. Vascular Smooth Muscle Diseases and Their Treatments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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