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Review ArticleReview Article

Manipulating Angiogenesis by Targeting Endothelial Metabolism: Hitting the Engine Rather than the Drivers—A New Perspective?

Lucas Treps, Lena-Christin Conradi, Ulrike Harjes and Peter Carmeliet
Yoshihiro Ishikawa, ASSOCIATE EDITOR
Pharmacological Reviews July 2016, 68 (3) 872-887; DOI: https://doi.org/10.1124/pr.116.012492
Lucas Treps
Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, and Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Leuven, Belgium
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Lena-Christin Conradi
Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, and Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Leuven, Belgium
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Ulrike Harjes
Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, and Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Leuven, Belgium
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Peter Carmeliet
Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, and Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Leuven, Belgium
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Yoshihiro Ishikawa
Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, and Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Leuven, Belgium
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Article Information

vol. 68 no. 3 872-887
DOI 
https://doi.org/10.1124/pr.116.012492
PubMed 
27363442

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online June 30, 2016.

Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Lucas Treps,
  2. Lena-Christin Conradi,
  3. Ulrike Harjes, and
  4. Peter Carmeliet
  1. Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, and Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Leuven, Belgium
  1. Yoshihiro Ishikawa, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. P. Carmeliet, Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Vlaams Instituut voor Biotechnologie, KU Leuven, Campus Gasthuisberg O&N4, Herestraat 49-912, B-3000, Leuven, Belgium. E-mail: peter.carmeliet{at}vib-kuleuven.be
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Pharmacological Reviews: 68 (3)
Pharmacological Reviews
Vol. 68, Issue 3
1 Jul 2016
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Review ArticleReview Article

Angiogenesis and Endothelial Metabolism

Lucas Treps, Lena-Christin Conradi, Ulrike Harjes and Peter Carmeliet
Pharmacological Reviews July 1, 2016, 68 (3) 872-887; DOI: https://doi.org/10.1124/pr.116.012492

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Review ArticleReview Article

Angiogenesis and Endothelial Metabolism

Lucas Treps, Lena-Christin Conradi, Ulrike Harjes and Peter Carmeliet
Pharmacological Reviews July 1, 2016, 68 (3) 872-887; DOI: https://doi.org/10.1124/pr.116.012492
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  • Article
    • Visual Overview
    • Abstract
    • I. Introduction
    • II. Genetic Control of Angiogenesis
    • III. Metabolic Control of Angiogenesis
    • IV. Endothelial Cell Metabolism Maladaptation in Disease
    • V. Pharmacological Targeting of Pathologic Angiogenesis
    • VI. Conclusion and Outlook
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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