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History
- Published online September 27, 2016.
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Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics
Author Information
- Rithwik Ramachandran,
- Christophe Altier,
- Katerina Oikonomopoulou, and
- Morley D. Hollenberg
- Inflammation Research Network-Snyder Institute for Chronic Disease, Department of Physiology & Pharmacology (R.R., C.A., M.D.H.) and Department of Medicine (M.D.H.),University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada; Department of Pathology and Laboratory Medicine, Toronto Western Hospital, Toronto, Ontario, Canada (K.O.); and Department of Physiology and Pharmacology, Western University, London, Ontario, Canada (R.R.)
- Paul A. Insel, ASSOCIATE EDITOR
- Address correspondence to:
Morley D. Hollenberg, Department of Physiology & Pharmacology, University of Calgary Cumming School of Medicine, 3330 Hospital Drive NW, Calgary AB, Canada T2N 4N1. E-mail: mhollenb{at}ucalgary.ca
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- Article
- Abstract
- I. Introduction
- II. Classification and Overview of Mechanisms Regulating Proteolytic Enzymes
- III. Proteinase-Mediated Signaling: Molecular Targets that Trigger the Response
- IV. Adhesion G Protein-Coupled Receptors: A Proteinase-Activated Receptor-like Tethered Ligand Signaling Mechanism Driven by Receptors with Intrinsic Proteinase Activity
- V. Proteolytic Regulation of Ion Channels
- VI. Therapeutic Targeting of the Proteolytic Signaling System
- VII. Future Perspectives
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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