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Review ArticleReview Article

Proteinases, Their Extracellular Targets, and Inflammatory Signaling

Rithwik Ramachandran, Christophe Altier, Katerina Oikonomopoulou and Morley D. Hollenberg
Paul A. Insel, ASSOCIATE EDITOR
Pharmacological Reviews October 2016, 68 (4) 1110-1142; DOI: https://doi.org/10.1124/pr.115.010991
Rithwik Ramachandran
Inflammation Research Network-Snyder Institute for Chronic Disease, Department of Physiology & Pharmacology (R.R., C.A., M.D.H.) and Department of Medicine (M.D.H.),University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada; Department of Pathology and Laboratory Medicine, Toronto Western Hospital, Toronto, Ontario, Canada (K.O.); and Department of Physiology and Pharmacology, Western University, London, Ontario, Canada (R.R.)
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Christophe Altier
Inflammation Research Network-Snyder Institute for Chronic Disease, Department of Physiology & Pharmacology (R.R., C.A., M.D.H.) and Department of Medicine (M.D.H.),University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada; Department of Pathology and Laboratory Medicine, Toronto Western Hospital, Toronto, Ontario, Canada (K.O.); and Department of Physiology and Pharmacology, Western University, London, Ontario, Canada (R.R.)
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Katerina Oikonomopoulou
Inflammation Research Network-Snyder Institute for Chronic Disease, Department of Physiology & Pharmacology (R.R., C.A., M.D.H.) and Department of Medicine (M.D.H.),University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada; Department of Pathology and Laboratory Medicine, Toronto Western Hospital, Toronto, Ontario, Canada (K.O.); and Department of Physiology and Pharmacology, Western University, London, Ontario, Canada (R.R.)
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Morley D. Hollenberg
Inflammation Research Network-Snyder Institute for Chronic Disease, Department of Physiology & Pharmacology (R.R., C.A., M.D.H.) and Department of Medicine (M.D.H.),University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada; Department of Pathology and Laboratory Medicine, Toronto Western Hospital, Toronto, Ontario, Canada (K.O.); and Department of Physiology and Pharmacology, Western University, London, Ontario, Canada (R.R.)
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Paul A. Insel
Inflammation Research Network-Snyder Institute for Chronic Disease, Department of Physiology & Pharmacology (R.R., C.A., M.D.H.) and Department of Medicine (M.D.H.),University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada; Department of Pathology and Laboratory Medicine, Toronto Western Hospital, Toronto, Ontario, Canada (K.O.); and Department of Physiology and Pharmacology, Western University, London, Ontario, Canada (R.R.)
Roles: ASSOCIATE EDITOR
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Article Information

vol. 68 no. 4 1110-1142
DOI 
https://doi.org/10.1124/pr.115.010991
PubMed 
27677721

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online September 27, 2016.

Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Rithwik Ramachandran,
  2. Christophe Altier,
  3. Katerina Oikonomopoulou, and
  4. Morley D. Hollenberg
  1. Inflammation Research Network-Snyder Institute for Chronic Disease, Department of Physiology & Pharmacology (R.R., C.A., M.D.H.) and Department of Medicine (M.D.H.),University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada; Department of Pathology and Laboratory Medicine, Toronto Western Hospital, Toronto, Ontario, Canada (K.O.); and Department of Physiology and Pharmacology, Western University, London, Ontario, Canada (R.R.)
  1. Paul A. Insel, ASSOCIATE EDITOR
  1. Address correspondence to:
    Morley D. Hollenberg, Department of Physiology & Pharmacology, University of Calgary Cumming School of Medicine, 3330 Hospital Drive NW, Calgary AB, Canada T2N 4N1. E-mail: mhollenb{at}ucalgary.ca
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Pharmacological Reviews: 68 (4)
Pharmacological Reviews
Vol. 68, Issue 4
1 Oct 2016
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Review ArticleReview Article

Proteinase-Mediated Signaling and Inflammation

Rithwik Ramachandran, Christophe Altier, Katerina Oikonomopoulou and Morley D. Hollenberg
Pharmacological Reviews October 1, 2016, 68 (4) 1110-1142; DOI: https://doi.org/10.1124/pr.115.010991

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Review ArticleReview Article

Proteinase-Mediated Signaling and Inflammation

Rithwik Ramachandran, Christophe Altier, Katerina Oikonomopoulou and Morley D. Hollenberg
Pharmacological Reviews October 1, 2016, 68 (4) 1110-1142; DOI: https://doi.org/10.1124/pr.115.010991
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  • Article
    • Abstract
    • I. Introduction
    • II. Classification and Overview of Mechanisms Regulating Proteolytic Enzymes
    • III. Proteinase-Mediated Signaling: Molecular Targets that Trigger the Response
    • IV. Adhesion G Protein-Coupled Receptors: A Proteinase-Activated Receptor-like Tethered Ligand Signaling Mechanism Driven by Receptors with Intrinsic Proteinase Activity
    • V. Proteolytic Regulation of Ion Channels
    • VI. Therapeutic Targeting of the Proteolytic Signaling System
    • VII. Future Perspectives
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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