Review ArticleReview Article
Proteinases, Their Extracellular Targets, and Inflammatory Signaling
Rithwik Ramachandran, Christophe Altier, Katerina Oikonomopoulou and Morley D. Hollenberg
Paul A. Insel, ASSOCIATE EDITOR
Pharmacological Reviews October 2016, 68 (4) 1110-1142; DOI: https://doi.org/10.1124/pr.115.010991
Rithwik Ramachandran
Inflammation Research Network-Snyder Institute for Chronic Disease, Department of Physiology & Pharmacology (R.R., C.A., M.D.H.) and Department of Medicine (M.D.H.),University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada; Department of Pathology and Laboratory Medicine, Toronto Western Hospital, Toronto, Ontario, Canada (K.O.); and Department of Physiology and Pharmacology, Western University, London, Ontario, Canada (R.R.)
Christophe Altier
Inflammation Research Network-Snyder Institute for Chronic Disease, Department of Physiology & Pharmacology (R.R., C.A., M.D.H.) and Department of Medicine (M.D.H.),University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada; Department of Pathology and Laboratory Medicine, Toronto Western Hospital, Toronto, Ontario, Canada (K.O.); and Department of Physiology and Pharmacology, Western University, London, Ontario, Canada (R.R.)
Katerina Oikonomopoulou
Inflammation Research Network-Snyder Institute for Chronic Disease, Department of Physiology & Pharmacology (R.R., C.A., M.D.H.) and Department of Medicine (M.D.H.),University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada; Department of Pathology and Laboratory Medicine, Toronto Western Hospital, Toronto, Ontario, Canada (K.O.); and Department of Physiology and Pharmacology, Western University, London, Ontario, Canada (R.R.)
Morley D. Hollenberg
Inflammation Research Network-Snyder Institute for Chronic Disease, Department of Physiology & Pharmacology (R.R., C.A., M.D.H.) and Department of Medicine (M.D.H.),University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada; Department of Pathology and Laboratory Medicine, Toronto Western Hospital, Toronto, Ontario, Canada (K.O.); and Department of Physiology and Pharmacology, Western University, London, Ontario, Canada (R.R.)
Paul A. Insel
Inflammation Research Network-Snyder Institute for Chronic Disease, Department of Physiology & Pharmacology (R.R., C.A., M.D.H.) and Department of Medicine (M.D.H.),University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada; Department of Pathology and Laboratory Medicine, Toronto Western Hospital, Toronto, Ontario, Canada (K.O.); and Department of Physiology and Pharmacology, Western University, London, Ontario, Canada (R.R.)
Roles: ASSOCIATE EDITOR

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In this issue
Review ArticleReview Article
Proteinase-Mediated Signaling and Inflammation
Rithwik Ramachandran, Christophe Altier, Katerina Oikonomopoulou and Morley D. Hollenberg
Pharmacological Reviews October 1, 2016, 68 (4) 1110-1142; DOI: https://doi.org/10.1124/pr.115.010991
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- Article
- Abstract
- I. Introduction
- II. Classification and Overview of Mechanisms Regulating Proteolytic Enzymes
- III. Proteinase-Mediated Signaling: Molecular Targets that Trigger the Response
- IV. Adhesion G Protein-Coupled Receptors: A Proteinase-Activated Receptor-like Tethered Ligand Signaling Mechanism Driven by Receptors with Intrinsic Proteinase Activity
- V. Proteolytic Regulation of Ion Channels
- VI. Therapeutic Targeting of the Proteolytic Signaling System
- VII. Future Perspectives
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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