Review ArticleReview Article
International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors
Csaba Szabo and Andreas Papapetropoulos
Eliot H. Ohlstein, ASSOCIATE EDITOR
Pharmacological Reviews October 2017, 69 (4) 497-564; DOI: https://doi.org/10.1124/pr.117.014050
Csaba Szabo
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, Texas (C.S.); Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Zografou, Greece (A.P.); and Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece (A.P.)
Andreas Papapetropoulos
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, Texas (C.S.); Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Zografou, Greece (A.P.); and Clinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece (A.P.)
Eliot H. Ohlstein
Roles: ASSOCIATE EDITOR
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Review ArticleReview Article
H2S Donors and H2S Biosynthesis Inhibitors
Csaba Szabo and Andreas Papapetropoulos
Pharmacological Reviews October 1, 2017, 69 (4) 497-564; DOI: https://doi.org/10.1124/pr.117.014050
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- Article
- Abstract
- I. Introduction
- II. The History of H2S as an Environmental Toxin
- III. H2S, as an Endogenous Biologic Mediator: Physiologic Roles
- IV. “H2S-Rich” and “H2S-Poor” Pathophysiological Conditions
- V. The Modes of H2S’s Biologic Actions
- VI. H2S Delivery via Inhalation of H2S Gas
- VII. Sulfide Salts (“Rapid-Release H2S Donors”)
- VIII. Sodium Polythionate (SG-1002)
- IX. IK-1001, a Pharmaceutically Acceptable, Parenteral Injectable Formulation of H2S
- X. Natural H2S Donors
- XI. S-Propargyl-Cysteine
- XII. “Old School” Spontaneous H2S Generators: Thioacetamide and Lawesson’s Reagent
- XIII. GYY4137 and Other Phosphinodiothioate Derivatives
- XIV. Carbonyl Sulfide and its Prodrugs
- XV. Nonregulated, Nontargeted, Miscellaneous H2S Donors
- XVI. pH-Controlled H2S Donors
- XVII. Redox-Activated H2S Donors
- XVIII. Photoactivated H2S Donors
- XIX. Esterase-Activated H2S Donors
- XX. Mitochondrially Targeted H2S Donors
- XXI. NO/H2S Hybrid Donors
- XXII. H2S-Donating Polymers and Special Pharmaceutical Formulations
- XXIII. Combined (or Hybrid) Molecules: H2S-Donating Derivatives of Clinically Used Drugs
- XXIV. Alternative Means to Increase Biologic H2S Levels
- XXV. A Brief Overview of Endogenous H2S Sources
- XXVI. Pharmacological Inhibitors of Cystathionine-γ-lyase
- XXVII. Pharmacological Inhibitors of Cystathionine-β-synthase
- XXVIII. Pharmacological Inhibitors of 3-Mercaptopyruvate Sulfurtransferase
- XXIX. Alternative Means to Decrease Biologic H2S Levels
- XXX. Conclusions and Future Directions
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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