Review ArticleReview Article
Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology
Sophie Layé, Agnès Nadjar, Corinne Joffre and Richard P. Bazinet
Robert Dantzer, ASSOCIATE EDITOR
Pharmacological Reviews January 2018, 70 (1) 12-38; DOI: https://doi.org/10.1124/pr.117.014092
Sophie Layé
Institut National pour la Recherche Agronomique and Bordeaux University, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France (S.L., A.N., C.J.); and Department of Nutritional Sciences, University of Toronto, Ontario, Canada (R.P.B.)
Agnès Nadjar
Institut National pour la Recherche Agronomique and Bordeaux University, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France (S.L., A.N., C.J.); and Department of Nutritional Sciences, University of Toronto, Ontario, Canada (R.P.B.)
Corinne Joffre
Institut National pour la Recherche Agronomique and Bordeaux University, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France (S.L., A.N., C.J.); and Department of Nutritional Sciences, University of Toronto, Ontario, Canada (R.P.B.)
Richard P. Bazinet
Institut National pour la Recherche Agronomique and Bordeaux University, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France (S.L., A.N., C.J.); and Department of Nutritional Sciences, University of Toronto, Ontario, Canada (R.P.B.)
Robert Dantzer
Roles: ASSOCIATE EDITOR

Submit a Response to This Article
Jump to comment:
No eLetters have been published for this article.
In this issue
Review ArticleReview Article
New Insights into the Impact of Omega-3 in Microglia
Sophie Layé, Agnès Nadjar, Corinne Joffre and Richard P. Bazinet
Pharmacological Reviews January 1, 2018, 70 (1) 12-38; DOI: https://doi.org/10.1124/pr.117.014092
Jump to section
- Article
- Abstract
- I. Introduction
- II. Definition of PUFAs
- III. Mechanisms of Entry of PUFAs into the Brain
- IV. Anti-Inflammatory Activities of n-3 PUFAs in the Brain
- V. Microglia as a Target for n-3 PUFAs and SPMs
- VI. Pharmacological Considerations on the Use of LC-PUFAs or SPMs as Effective Anti-Inflammatory Drugs in the Brain—Clinical Use
- VII. Conclusion
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement