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Open Access

WNT Signaling in Cardiac and Vascular Disease

Sébastien Foulquier, Evangelos P. Daskalopoulos, Gentian Lluri, Kevin C. M. Hermans, Arjun Deb and W. Matthijs Blankesteijn
Martin C. Michel, ASSOCIATE EDITOR
Pharmacological Reviews January 2018, 70 (1) 68-141; DOI: https://doi.org/10.1124/pr.117.013896
Sébastien Foulquier
Department of Pharmacology and Toxicology, Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands (S.F., K.C.M.H., W.M.B.); Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels, Belgium (E.P.D.); Department of Medicine, Division of Cardiology, David Geffen School of Medicine (G.L., A.D.); and Department of Molecular Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, California (A.D.)
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Evangelos P. Daskalopoulos
Department of Pharmacology and Toxicology, Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands (S.F., K.C.M.H., W.M.B.); Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels, Belgium (E.P.D.); Department of Medicine, Division of Cardiology, David Geffen School of Medicine (G.L., A.D.); and Department of Molecular Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, California (A.D.)
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Gentian Lluri
Department of Pharmacology and Toxicology, Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands (S.F., K.C.M.H., W.M.B.); Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels, Belgium (E.P.D.); Department of Medicine, Division of Cardiology, David Geffen School of Medicine (G.L., A.D.); and Department of Molecular Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, California (A.D.)
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Kevin C. M. Hermans
Department of Pharmacology and Toxicology, Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands (S.F., K.C.M.H., W.M.B.); Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels, Belgium (E.P.D.); Department of Medicine, Division of Cardiology, David Geffen School of Medicine (G.L., A.D.); and Department of Molecular Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, California (A.D.)
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Arjun Deb
Department of Pharmacology and Toxicology, Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands (S.F., K.C.M.H., W.M.B.); Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels, Belgium (E.P.D.); Department of Medicine, Division of Cardiology, David Geffen School of Medicine (G.L., A.D.); and Department of Molecular Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, California (A.D.)
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W. Matthijs Blankesteijn
Department of Pharmacology and Toxicology, Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands (S.F., K.C.M.H., W.M.B.); Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels, Belgium (E.P.D.); Department of Medicine, Division of Cardiology, David Geffen School of Medicine (G.L., A.D.); and Department of Molecular Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, California (A.D.)
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Martin C. Michel
Roles: ASSOCIATE EDITOR
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Pharmacological Reviews: 70 (1)
Pharmacological Reviews
Vol. 70, Issue 1
1 Jan 2018
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Review ArticleReview Article

WNT Signaling in Cardiovascular Disease

Sébastien Foulquier, Evangelos P. Daskalopoulos, Gentian Lluri, Kevin C. M. Hermans, Arjun Deb and W. Matthijs Blankesteijn
Pharmacological Reviews January 1, 2018, 70 (1) 68-141; DOI: https://doi.org/10.1124/pr.117.013896

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Review ArticleReview Article

WNT Signaling in Cardiovascular Disease

Sébastien Foulquier, Evangelos P. Daskalopoulos, Gentian Lluri, Kevin C. M. Hermans, Arjun Deb and W. Matthijs Blankesteijn
Pharmacological Reviews January 1, 2018, 70 (1) 68-141; DOI: https://doi.org/10.1124/pr.117.013896
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  • Article
    • Abstract
    • I. Introduction
    • II. The History of WNT Signaling
    • III. Components of the Receptor Complex
    • IV. Regulation of WNT Signaling
    • V. Signal Transduction
    • VI. WNT Signaling in Cardiac and Vascular Development
    • VII. WNT Signaling in Vascular Disease
    • VIII. WNT Signaling in Cardiac Disease
    • IX. WNT Signaling in Stem Cells
    • X. Crosstalk between WNT Signaling and Other Signal Transduction Pathways
    • XI. Therapeutic Interventions
    • XII. Future Perspectives
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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