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Review ArticleReview Article

Adverse Neuropsychiatric Events and Recreational Use of Efavirenz and Other HIV-1 Antiretroviral Drugs

Dhwanil A. Dalwadi, Luis Ozuna, Brian H. Harvey, Michelle Viljoen and John A. Schetz
Charles P. France, ASSOCIATE EDITOR
Pharmacological Reviews July 2018, 70 (3) 684-711; DOI: https://doi.org/10.1124/pr.117.013706
Dhwanil A. Dalwadi
Institute for Healthy Aging, Center for Neuroscience Discovery, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas (D.A.D., L.O., J.A.S.); Centre of Excellence for Pharmaceutical Sciences (PharmaCen), Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom, South Africa (B.H.H.); and Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa (M.V.)
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Luis Ozuna
Institute for Healthy Aging, Center for Neuroscience Discovery, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas (D.A.D., L.O., J.A.S.); Centre of Excellence for Pharmaceutical Sciences (PharmaCen), Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom, South Africa (B.H.H.); and Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa (M.V.)
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Brian H. Harvey
Institute for Healthy Aging, Center for Neuroscience Discovery, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas (D.A.D., L.O., J.A.S.); Centre of Excellence for Pharmaceutical Sciences (PharmaCen), Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom, South Africa (B.H.H.); and Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa (M.V.)
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Michelle Viljoen
Institute for Healthy Aging, Center for Neuroscience Discovery, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas (D.A.D., L.O., J.A.S.); Centre of Excellence for Pharmaceutical Sciences (PharmaCen), Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom, South Africa (B.H.H.); and Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa (M.V.)
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John A. Schetz
Institute for Healthy Aging, Center for Neuroscience Discovery, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas (D.A.D., L.O., J.A.S.); Centre of Excellence for Pharmaceutical Sciences (PharmaCen), Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom, South Africa (B.H.H.); and Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa (M.V.)
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Charles P. France
Roles: ASSOCIATE EDITOR
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Article Information

vol. 70 no. 3 684-711
DOI 
https://doi.org/10.1124/pr.117.013706
PubMed 
29945900

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online June 26, 2018.

Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Dhwanil A. Dalwadi,
  2. Luis Ozuna,
  3. Brian H. Harvey,
  4. Michelle Viljoen, and
  5. John A. Schetz
  1. Institute for Healthy Aging, Center for Neuroscience Discovery, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas (D.A.D., L.O., J.A.S.); Centre of Excellence for Pharmaceutical Sciences (PharmaCen), Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom, South Africa (B.H.H.); and Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa (M.V.)
  1. Charles P. France, ASSOCIATE EDITOR
  1. Address correspondence to:
    John A. Schetz, UNT Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107. E-mail: John.Schetz{at}unthsc.edu
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Pharmacological Reviews: 70 (3)
Pharmacological Reviews
Vol. 70, Issue 3
1 Jul 2018
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Review ArticleReview Article

Neuropsychiatric Side Effects and Illicit Use of Efavirenz

Dhwanil A. Dalwadi, Luis Ozuna, Brian H. Harvey, Michelle Viljoen and John A. Schetz
Pharmacological Reviews July 1, 2018, 70 (3) 684-711; DOI: https://doi.org/10.1124/pr.117.013706

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Review ArticleReview Article

Neuropsychiatric Side Effects and Illicit Use of Efavirenz

Dhwanil A. Dalwadi, Luis Ozuna, Brian H. Harvey, Michelle Viljoen and John A. Schetz
Pharmacological Reviews July 1, 2018, 70 (3) 684-711; DOI: https://doi.org/10.1124/pr.117.013706
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  • Article
    • Abstract
    • I. Historical Perspective of Antiretroviral Drugs and Highly Active Antiretroviral Therapy
    • II. Neuropsychiatric Adverse Event Associated with Antiretroviral Drugs
    • III. Recreational Use of Efavirenz
    • IV. Factors Increasing Efavirenz Plasma Levels
    • V. Molecular Mechanisms and Receptor Pharmacology of Efavirenz
    • VI. Possible Association of Efavirenz with Human Immunodeficiency Virus-Associated Neurocognitive Disorder
    • VII. Summary of Key Points
    • Authorship Contributions
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