Review ArticleReview Article
Adverse Neuropsychiatric Events and Recreational Use of Efavirenz and Other HIV-1 Antiretroviral Drugs
Dhwanil A. Dalwadi, Luis Ozuna, Brian H. Harvey, Michelle Viljoen and John A. Schetz
Charles P. France, ASSOCIATE EDITOR
Pharmacological Reviews July 2018, 70 (3) 684-711; DOI: https://doi.org/10.1124/pr.117.013706
Dhwanil A. Dalwadi
Institute for Healthy Aging, Center for Neuroscience Discovery, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas (D.A.D., L.O., J.A.S.); Centre of Excellence for Pharmaceutical Sciences (PharmaCen), Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom, South Africa (B.H.H.); and Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa (M.V.)
Luis Ozuna
Institute for Healthy Aging, Center for Neuroscience Discovery, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas (D.A.D., L.O., J.A.S.); Centre of Excellence for Pharmaceutical Sciences (PharmaCen), Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom, South Africa (B.H.H.); and Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa (M.V.)
Brian H. Harvey
Institute for Healthy Aging, Center for Neuroscience Discovery, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas (D.A.D., L.O., J.A.S.); Centre of Excellence for Pharmaceutical Sciences (PharmaCen), Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom, South Africa (B.H.H.); and Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa (M.V.)
Michelle Viljoen
Institute for Healthy Aging, Center for Neuroscience Discovery, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas (D.A.D., L.O., J.A.S.); Centre of Excellence for Pharmaceutical Sciences (PharmaCen), Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom, South Africa (B.H.H.); and Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa (M.V.)
John A. Schetz
Institute for Healthy Aging, Center for Neuroscience Discovery, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas (D.A.D., L.O., J.A.S.); Centre of Excellence for Pharmaceutical Sciences (PharmaCen), Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom, South Africa (B.H.H.); and Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Bellville, South Africa (M.V.)
Charles P. France
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
Neuropsychiatric Side Effects and Illicit Use of Efavirenz
Dhwanil A. Dalwadi, Luis Ozuna, Brian H. Harvey, Michelle Viljoen and John A. Schetz
Pharmacological Reviews July 1, 2018, 70 (3) 684-711; DOI: https://doi.org/10.1124/pr.117.013706
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- Article
- Abstract
- I. Historical Perspective of Antiretroviral Drugs and Highly Active Antiretroviral Therapy
- II. Neuropsychiatric Adverse Event Associated with Antiretroviral Drugs
- III. Recreational Use of Efavirenz
- IV. Factors Increasing Efavirenz Plasma Levels
- V. Molecular Mechanisms and Receptor Pharmacology of Efavirenz
- VI. Possible Association of Efavirenz with Human Immunodeficiency Virus-Associated Neurocognitive Disorder
- VII. Summary of Key Points
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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