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Review ArticleReview Article

The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation

John D. Salamone, Mercè Correa, Sarah Ferrigno, Jen-Hau Yang, Renee A. Rotolo and Rose E. Presby
Robert Dantzer, ASSOCIATE EDITOR
Pharmacological Reviews October 2018, 70 (4) 747-762; DOI: https://doi.org/10.1124/pr.117.015107
John D. Salamone
Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut (J.D.S., S.F., J.-H.Y., R.A.R., R.E.P.); and Area de Psicobiologia, Universitat de Jaume I, Castelló, Spain (M.C.)
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Mercè Correa
Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut (J.D.S., S.F., J.-H.Y., R.A.R., R.E.P.); and Area de Psicobiologia, Universitat de Jaume I, Castelló, Spain (M.C.)
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Sarah Ferrigno
Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut (J.D.S., S.F., J.-H.Y., R.A.R., R.E.P.); and Area de Psicobiologia, Universitat de Jaume I, Castelló, Spain (M.C.)
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Jen-Hau Yang
Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut (J.D.S., S.F., J.-H.Y., R.A.R., R.E.P.); and Area de Psicobiologia, Universitat de Jaume I, Castelló, Spain (M.C.)
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Renee A. Rotolo
Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut (J.D.S., S.F., J.-H.Y., R.A.R., R.E.P.); and Area de Psicobiologia, Universitat de Jaume I, Castelló, Spain (M.C.)
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Rose E. Presby
Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut (J.D.S., S.F., J.-H.Y., R.A.R., R.E.P.); and Area de Psicobiologia, Universitat de Jaume I, Castelló, Spain (M.C.)
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Robert Dantzer
Roles: ASSOCIATE EDITOR
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Article Information

vol. 70 no. 4 747-762
DOI 
https://doi.org/10.1124/pr.117.015107
PubMed 
30209181

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online September 12, 2018.

Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. John D. Salamone,
  2. Mercè Correa,
  3. Sarah Ferrigno,
  4. Jen-Hau Yang,
  5. Renee A. Rotolo, and
  6. Rose E. Presby
  1. Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut (J.D.S., S.F., J.-H.Y., R.A.R., R.E.P.); and Area de Psicobiologia, Universitat de Jaume I, Castelló, Spain (M.C.)
  1. Robert Dantzer, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. John D. Salamone, Department of Psychological Sciences, Division of Behavioral Neuroscience, University of Connecticut, Storrs, CT 06269-1020. E-mail: john.salamone{at}uconn.edu
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Pharmacological Reviews: 70 (4)
Pharmacological Reviews
Vol. 70, Issue 4
1 Oct 2018
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Review ArticleReview Article

Pharmacology of Effort-Related Aspects of Motivation

John D. Salamone, Mercè Correa, Sarah Ferrigno, Jen-Hau Yang, Renee A. Rotolo and Rose E. Presby
Pharmacological Reviews October 1, 2018, 70 (4) 747-762; DOI: https://doi.org/10.1124/pr.117.015107

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Review ArticleReview Article

Pharmacology of Effort-Related Aspects of Motivation

John D. Salamone, Mercè Correa, Sarah Ferrigno, Jen-Hau Yang, Renee A. Rotolo and Rose E. Presby
Pharmacological Reviews October 1, 2018, 70 (4) 747-762; DOI: https://doi.org/10.1124/pr.117.015107
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  • Article
    • Abstract
    • I. Introduction: Motivational Processes and Psychopharmacology
    • II. Neural Circuits and Transmitters Mediating Effort-Based Choice: Mesolimbic Dopamine
    • III. Behavioral Effects of Dopaminergic Manipulations on Effort-Related Tasks Are Not Due to Broad or General Changes in Reward, Temporal Processing, or Motor Incapacity
    • IV. What Fundamental Processes Underlie the Low-Effort Bias Induced by Interference with Dopamine Transmission?
    • V. Neural Circuits and Transmitters Mediating Effort-Based Choice: Adenosine, GABA, and Nondopaminergic Components of the Circuit
    • VI. Clinical Implications: Targeting Drugs for the Potential Treatment of Effort-Based Dysfunctions
    • VII. Conclusions
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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