Review ArticleReview Article
The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation
John D. Salamone, Mercè Correa, Sarah Ferrigno, Jen-Hau Yang, Renee A. Rotolo and Rose E. Presby
Robert Dantzer, ASSOCIATE EDITOR
Pharmacological Reviews October 2018, 70 (4) 747-762; DOI: https://doi.org/10.1124/pr.117.015107
John D. Salamone
Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut (J.D.S., S.F., J.-H.Y., R.A.R., R.E.P.); and Area de Psicobiologia, Universitat de Jaume I, Castelló, Spain (M.C.)
Mercè Correa
Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut (J.D.S., S.F., J.-H.Y., R.A.R., R.E.P.); and Area de Psicobiologia, Universitat de Jaume I, Castelló, Spain (M.C.)
Sarah Ferrigno
Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut (J.D.S., S.F., J.-H.Y., R.A.R., R.E.P.); and Area de Psicobiologia, Universitat de Jaume I, Castelló, Spain (M.C.)
Jen-Hau Yang
Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut (J.D.S., S.F., J.-H.Y., R.A.R., R.E.P.); and Area de Psicobiologia, Universitat de Jaume I, Castelló, Spain (M.C.)
Renee A. Rotolo
Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut (J.D.S., S.F., J.-H.Y., R.A.R., R.E.P.); and Area de Psicobiologia, Universitat de Jaume I, Castelló, Spain (M.C.)
Rose E. Presby
Department of Psychological Sciences, University of Connecticut, Storrs, Connecticut (J.D.S., S.F., J.-H.Y., R.A.R., R.E.P.); and Area de Psicobiologia, Universitat de Jaume I, Castelló, Spain (M.C.)
Robert Dantzer
Roles: ASSOCIATE EDITOR

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In this issue
Review ArticleReview Article
Pharmacology of Effort-Related Aspects of Motivation
John D. Salamone, Mercè Correa, Sarah Ferrigno, Jen-Hau Yang, Renee A. Rotolo and Rose E. Presby
Pharmacological Reviews October 1, 2018, 70 (4) 747-762; DOI: https://doi.org/10.1124/pr.117.015107
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- Article
- Abstract
- I. Introduction: Motivational Processes and Psychopharmacology
- II. Neural Circuits and Transmitters Mediating Effort-Based Choice: Mesolimbic Dopamine
- III. Behavioral Effects of Dopaminergic Manipulations on Effort-Related Tasks Are Not Due to Broad or General Changes in Reward, Temporal Processing, or Motor Incapacity
- IV. What Fundamental Processes Underlie the Low-Effort Bias Induced by Interference with Dopamine Transmission?
- V. Neural Circuits and Transmitters Mediating Effort-Based Choice: Adenosine, GABA, and Nondopaminergic Components of the Circuit
- VI. Clinical Implications: Targeting Drugs for the Potential Treatment of Effort-Based Dysfunctions
- VII. Conclusions
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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