Table of Contents

Review Articles

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  Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges

  Annika Højrup Runegaard, Ciarán Martin Fitzpatrick, David Paul Drucker Woldbye, Jesper Tobias Andreasen, Andreas Toft Sørensen and Ulrik Gether

  Lynette C. Daws, ASSOCIATE EDITOR

  Pharmacological Reviews April 2019, 71 (2) 123-156; DOI: https://doi.org/10.1124/pr.117.013995
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  Target Site Delivery and Residence of Nanomedicines: Application of Quantitative Systems Pharmacology

  Jessie L.-S. Au, Roberto A. Abbiati, M. Guillaume Wientjes and Ze Lu

  Yoshihiro Ishikawa, ASSOCIATE EDITOR

  Pharmacological Reviews April 2019, 71 (2) 157-169; DOI: https://doi.org/10.1124/pr.118.016816
• Open Access

  A Practical Review of Proteasome Pharmacology

  Tiffany A. Thibaudeau and David M. Smith

  Qiang Ma, ASSOCIATE EDITOR

  Pharmacological Reviews April 2019, 71 (2) 170-197; DOI: https://doi.org/10.1124/pr.117.015370
• Open Access

  Gut Reactions: Breaking Down Xenobiotic–Microbiome Interactions

  Gerard Clarke, Kiran V. Sandhu, Brendan T. Griffin, Timothy G. Dinan, John F. Cryan and Niall P. Hyland

  Charles P. France, ASSOCIATE EDITOR

  Pharmacological Reviews April 2019, 71 (2) 198-224; DOI: https://doi.org/10.1124/pr.118.015768
• Open Access

  Core Outcome Measures in Preclinical Assessment of Candidate Analgesics

  S. Stevens Negus

  Michael A. Nader, ASSOCIATE EDITOR

  Pharmacological Reviews April 2019, 71 (2) 225-266; DOI: https://doi.org/10.1124/pr.118.017210
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  Biased Receptor Signaling in Drug Discovery

  Terry Kenakin

  Eric L. Barker, ASSOCIATE EDITOR

  Pharmacological Reviews April 2019, 71 (2) 267-315; DOI: https://doi.org/10.1124/pr.118.016790