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Review ArticleReview Article

Target Site Delivery and Residence of Nanomedicines: Application of Quantitative Systems Pharmacology

Jessie L.-S. Au, Roberto A. Abbiati, M. Guillaume Wientjes and Ze Lu
Yoshihiro Ishikawa, ASSOCIATE EDITOR
Pharmacological Reviews April 2019, 71 (2) 157-169; DOI: https://doi.org/10.1124/pr.118.016816
Jessie L.-S. Au
Institute of Quantitative Systems Pharmacology, Carlsbad, California (J.L.-S.A., R.A.A., M.G.W., Z.L.); Department of Pharmaceutical Sciences, University of Oklahoma, Oklahoma City, Oklahoma (J.L.-S.A., R.A.A.); Optimum Therapeutics LLC, Carlsbad, California (J.L.-S.A., M.G.W., Z.L.); and College of Pharmacy, Taipei Medical University, Taipei, Taiwan, Republic of China (J.L.-S.A.)
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Roberto A. Abbiati
Institute of Quantitative Systems Pharmacology, Carlsbad, California (J.L.-S.A., R.A.A., M.G.W., Z.L.); Department of Pharmaceutical Sciences, University of Oklahoma, Oklahoma City, Oklahoma (J.L.-S.A., R.A.A.); Optimum Therapeutics LLC, Carlsbad, California (J.L.-S.A., M.G.W., Z.L.); and College of Pharmacy, Taipei Medical University, Taipei, Taiwan, Republic of China (J.L.-S.A.)
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M. Guillaume Wientjes
Institute of Quantitative Systems Pharmacology, Carlsbad, California (J.L.-S.A., R.A.A., M.G.W., Z.L.); Department of Pharmaceutical Sciences, University of Oklahoma, Oklahoma City, Oklahoma (J.L.-S.A., R.A.A.); Optimum Therapeutics LLC, Carlsbad, California (J.L.-S.A., M.G.W., Z.L.); and College of Pharmacy, Taipei Medical University, Taipei, Taiwan, Republic of China (J.L.-S.A.)
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Ze Lu
Institute of Quantitative Systems Pharmacology, Carlsbad, California (J.L.-S.A., R.A.A., M.G.W., Z.L.); Department of Pharmaceutical Sciences, University of Oklahoma, Oklahoma City, Oklahoma (J.L.-S.A., R.A.A.); Optimum Therapeutics LLC, Carlsbad, California (J.L.-S.A., M.G.W., Z.L.); and College of Pharmacy, Taipei Medical University, Taipei, Taiwan, Republic of China (J.L.-S.A.)
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Yoshihiro Ishikawa
Roles: ASSOCIATE EDITOR
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Article Information

vol. 71 no. 2 157-169
DOI 
https://doi.org/10.1124/pr.118.016816
PubMed 
30846487

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online March 7, 2019.

Copyright & Usage 
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jessie L.-S. Au,
  2. Roberto A. Abbiati,
  3. M. Guillaume Wientjes, and
  4. Ze Lu
  1. Institute of Quantitative Systems Pharmacology, Carlsbad, California (J.L.-S.A., R.A.A., M.G.W., Z.L.); Department of Pharmaceutical Sciences, University of Oklahoma, Oklahoma City, Oklahoma (J.L.-S.A., R.A.A.); Optimum Therapeutics LLC, Carlsbad, California (J.L.-S.A., M.G.W., Z.L.); and College of Pharmacy, Taipei Medical University, Taipei, Taiwan, Republic of China (J.L.-S.A.)
  1. Yoshihiro Ishikawa, ASSOCIATE EDITOR
  1. Address correspondence to:
    Jessie L.-S. Au, Institute of Quantitative Systems Pharmacology, 1815 Aston Ave., Suite 107, Carlsbad, CA 92008. E-mail: jau{at}i-qsp.org
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Pharmacological Reviews: 71 (2)
Pharmacological Reviews
Vol. 71, Issue 2
1 Apr 2019
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Review ArticleReview Article

QSP to Evaluate Target Site Delivery of Nanomedicines

Jessie L.-S. Au, Roberto A. Abbiati, M. Guillaume Wientjes and Ze Lu
Pharmacological Reviews April 1, 2019, 71 (2) 157-169; DOI: https://doi.org/10.1124/pr.118.016816

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Review ArticleReview Article

QSP to Evaluate Target Site Delivery of Nanomedicines

Jessie L.-S. Au, Roberto A. Abbiati, M. Guillaume Wientjes and Ze Lu
Pharmacological Reviews April 1, 2019, 71 (2) 157-169; DOI: https://doi.org/10.1124/pr.118.016816
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  • Article
    • Abstract
    • I. Introduction
    • II. Transport from Blood to the Tissue Interstitium
    • III. Interactions with the Extracellular Matrix and Cells
    • IV. Intracellular Trafficking
    • V. Examples of Applying Quantitative Systems Pharmacology to Estimate the Target Site Delivery and Residence of Small Molecule Drugs and Nanosized Medicines
    • VI. Interaction of Nanosized Medicine and Proteins to Form Protein Corona
    • VII. Unique Regulatory Issues Regarding Nanosized Medicine Products
    • VIII. Conclusions and Perspectives
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
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  • eLetters
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