Cover Caption

About the cover: The schematics on the top row depict brain organization in psychopathologies such as depression in which high-level priors (e.g. instantiated by the default-mode network) are over-weighted (thick top-down arrow) causing a suppression of and insensitivity to bottom-up signalling (e.g. stemming from the limbic system). The bottom row depicts brain organization under a psychedelic. See the article by Carhart-Harris and Friston. (dx.doi.org/10.1124/pr.118.017160)