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Open Access

5-HT3 Receptor Antagonists in Neurologic and Neuropsychiatric Disorders: The Iceberg Still Lies beneath the Surface

Gohar Fakhfouri, Reza Rahimian, Jonas Dyhrfjeld-Johnsen, Mohammad Reza Zirak and Jean-Martin Beaulieu
Jeffrey M. Witkin, ASSOCIATE EDITOR
Pharmacological Reviews July 2019, 71 (3) 383-412; DOI: https://doi.org/10.1124/pr.118.015487
Gohar Fakhfouri
Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Centre, Laval University, Quebec, Quebec, Canada (G.F., R.R.); Sensorion SA, Montpellier, France (J.D.-J.); Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran (M.R.Z.); and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada (J.-M.B.)
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Reza Rahimian
Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Centre, Laval University, Quebec, Quebec, Canada (G.F., R.R.); Sensorion SA, Montpellier, France (J.D.-J.); Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran (M.R.Z.); and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada (J.-M.B.)
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Jonas Dyhrfjeld-Johnsen
Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Centre, Laval University, Quebec, Quebec, Canada (G.F., R.R.); Sensorion SA, Montpellier, France (J.D.-J.); Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran (M.R.Z.); and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada (J.-M.B.)
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Mohammad Reza Zirak
Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Centre, Laval University, Quebec, Quebec, Canada (G.F., R.R.); Sensorion SA, Montpellier, France (J.D.-J.); Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran (M.R.Z.); and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada (J.-M.B.)
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Jean-Martin Beaulieu
Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Centre, Laval University, Quebec, Quebec, Canada (G.F., R.R.); Sensorion SA, Montpellier, France (J.D.-J.); Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran (M.R.Z.); and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada (J.-M.B.)
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Jeffrey M. Witkin
Roles: ASSOCIATE EDITOR
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Article Information

vol. 71 no. 3 383-412
DOI 
https://doi.org/10.1124/pr.118.015487
PubMed 
31243157

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online June 26, 2019.

Copyright & Usage 
Copyright © 2019 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

Author Information

  1. Gohar Fakhfouri1,
  2. Reza Rahimian1,
  3. Jonas Dyhrfjeld-Johnsen,
  4. Mohammad Reza Zirak, and
  5. Jean-Martin Beaulieu
  1. Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Centre, Laval University, Quebec, Quebec, Canada (G.F., R.R.); Sensorion SA, Montpellier, France (J.D.-J.); Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran (M.R.Z.); and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada (J.-M.B.)
  1. Jeffrey M. Witkin, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. Jean-Martin Beaulieu, Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Medical Science Building, Toronto, ON M5S 1A8, Canada. E-mail: martin.beaulieu{at}utoronto.ca
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Pharmacological Reviews: 71 (3)
Pharmacological Reviews
Vol. 71, Issue 3
1 Jul 2019
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Review ArticleReview Article

5-HT3 Receptor Antagonists in Neurology and Neuropsychiatry

Gohar Fakhfouri, Reza Rahimian, Jonas Dyhrfjeld-Johnsen, Mohammad Reza Zirak and Jean-Martin Beaulieu
Pharmacological Reviews July 1, 2019, 71 (3) 383-412; DOI: https://doi.org/10.1124/pr.118.015487

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Review ArticleReview Article

5-HT3 Receptor Antagonists in Neurology and Neuropsychiatry

Gohar Fakhfouri, Reza Rahimian, Jonas Dyhrfjeld-Johnsen, Mohammad Reza Zirak and Jean-Martin Beaulieu
Pharmacological Reviews July 1, 2019, 71 (3) 383-412; DOI: https://doi.org/10.1124/pr.118.015487
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  • Article
    • Abstract
    • I. Introduction
    • II. 5-HT3 Receptor Structure, Distribution, and Ligands
    • III. Biologic Effects of 5-HT3 Receptor Antagonists, a Final Remark
    • IV. 5-HT3 Receptor Antagonists in Neurologic Disorders
    • V. 5-HT3 Receptor Antagonists in Psychiatric Disorders
    • VI. Concluding Remarks
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