Review ArticleReview Article
Open Access
5-HT3 Receptor Antagonists in Neurologic and Neuropsychiatric Disorders: The Iceberg Still Lies beneath the Surface
Gohar Fakhfouri, Reza Rahimian, Jonas Dyhrfjeld-Johnsen, Mohammad Reza Zirak and Jean-Martin Beaulieu
Jeffrey M. Witkin, ASSOCIATE EDITOR
Pharmacological Reviews July 2019, 71 (3) 383-412; DOI: https://doi.org/10.1124/pr.118.015487
Gohar Fakhfouri
Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Centre, Laval University, Quebec, Quebec, Canada (G.F., R.R.); Sensorion SA, Montpellier, France (J.D.-J.); Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran (M.R.Z.); and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada (J.-M.B.)
Reza Rahimian
Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Centre, Laval University, Quebec, Quebec, Canada (G.F., R.R.); Sensorion SA, Montpellier, France (J.D.-J.); Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran (M.R.Z.); and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada (J.-M.B.)
Jonas Dyhrfjeld-Johnsen
Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Centre, Laval University, Quebec, Quebec, Canada (G.F., R.R.); Sensorion SA, Montpellier, France (J.D.-J.); Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran (M.R.Z.); and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada (J.-M.B.)
Mohammad Reza Zirak
Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Centre, Laval University, Quebec, Quebec, Canada (G.F., R.R.); Sensorion SA, Montpellier, France (J.D.-J.); Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran (M.R.Z.); and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada (J.-M.B.)
Jean-Martin Beaulieu
Department of Psychiatry and Neuroscience, Faculty of Medicine, CERVO Brain Research Centre, Laval University, Quebec, Quebec, Canada (G.F., R.R.); Sensorion SA, Montpellier, France (J.D.-J.); Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran (M.R.Z.); and Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada (J.-M.B.)
Jeffrey M. Witkin
Roles: ASSOCIATE EDITOR

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In this issue
Review ArticleReview Article
5-HT3 Receptor Antagonists in Neurology and Neuropsychiatry
Gohar Fakhfouri, Reza Rahimian, Jonas Dyhrfjeld-Johnsen, Mohammad Reza Zirak and Jean-Martin Beaulieu
Pharmacological Reviews July 1, 2019, 71 (3) 383-412; DOI: https://doi.org/10.1124/pr.118.015487
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- Article
- Abstract
- I. Introduction
- II. 5-HT3 Receptor Structure, Distribution, and Ligands
- III. Biologic Effects of 5-HT3 Receptor Antagonists, a Final Remark
- IV. 5-HT3 Receptor Antagonists in Neurologic Disorders
- V. 5-HT3 Receptor Antagonists in Psychiatric Disorders
- VI. Concluding Remarks
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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