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History
- Published online August 30, 2019.
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Copyright © 2019 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.
Author Information
- Nicholas Denomme,
- Jacob M. Hull, and
- George A. Mashour
- Lori L. Isom, ASSOCIATE EDITOR
- Address correspondence to:
Dr. George A. Mashour, Department of Anesthesiology, Center for Consciousness Science, University of Michigan Medical School, 1500 E. Medical Center Drive, 1H247 University Hospital, SPC-5048, Ann Arbor, MI, 48109-5048. E-mail: gmashour{at}umich.edu
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- Article
- Abstract
- I. Introduction
- II. Basic Pharmacology and Physicochemical Properties of the Halogenated Ethers
- III. Basic Overview of Voltage-Gated Sodium Channel Biology
- IV. Molecular Interactions of Halogenated Ethers with Voltage-Gated Sodium Channels
- V. Structural and Computational Studies Using Prokaryotic Voltage-Gated Sodium Channels
- VI. Presynaptic Voltage-Gated Sodium Channel Inhibition Leads to Depressed Neurotransmission
- VII. In Vivo Modulation of Halogenated Ether Anesthesia
- VIII. Conclusion
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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