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Open Access

Role of Voltage-Gated Sodium Channels in the Mechanism of Ether-Induced Unconsciousness

Nicholas Denomme, Jacob M. Hull and George A. Mashour
Lori L. Isom, ASSOCIATE EDITOR
Pharmacological Reviews October 2019, 71 (4) 450-466; DOI: https://doi.org/10.1124/pr.118.016592
Nicholas Denomme
Departments of Pharmacology (N.D.) and Anesthesiology (G.A.M.), Center for Consciousness Science (N.D., G.A.M.), and Neuroscience Graduate Program (J.M.H., G.A.M.), University of Michigan, Ann Arbor, Michigan
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Jacob M. Hull
Departments of Pharmacology (N.D.) and Anesthesiology (G.A.M.), Center for Consciousness Science (N.D., G.A.M.), and Neuroscience Graduate Program (J.M.H., G.A.M.), University of Michigan, Ann Arbor, Michigan
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George A. Mashour
Departments of Pharmacology (N.D.) and Anesthesiology (G.A.M.), Center for Consciousness Science (N.D., G.A.M.), and Neuroscience Graduate Program (J.M.H., G.A.M.), University of Michigan, Ann Arbor, Michigan
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Lori L. Isom
Roles: ASSOCIATE EDITOR
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Article Information

vol. 71 no. 4 450-466
DOI 
https://doi.org/10.1124/pr.118.016592
PubMed 
31471460

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online August 30, 2019.

Copyright & Usage 
Copyright © 2019 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

Author Information

  1. Nicholas Denomme,
  2. Jacob M. Hull, and
  3. George A. Mashour
  1. Departments of Pharmacology (N.D.) and Anesthesiology (G.A.M.), Center for Consciousness Science (N.D., G.A.M.), and Neuroscience Graduate Program (J.M.H., G.A.M.), University of Michigan, Ann Arbor, Michigan
  1. Lori L. Isom, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. George A. Mashour, Department of Anesthesiology, Center for Consciousness Science, University of Michigan Medical School, 1500 E. Medical Center Drive, 1H247 University Hospital, SPC-5048, Ann Arbor, MI, 48109-5048. E-mail: gmashour{at}umich.edu
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Pharmacological Reviews: 71 (4)
Pharmacological Reviews
Vol. 71, Issue 4
1 Oct 2019
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Review ArticleReview Article

Sodium Channels and General Anesthesia

Nicholas Denomme, Jacob M. Hull and George A. Mashour
Pharmacological Reviews October 1, 2019, 71 (4) 450-466; DOI: https://doi.org/10.1124/pr.118.016592

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Review ArticleReview Article

Sodium Channels and General Anesthesia

Nicholas Denomme, Jacob M. Hull and George A. Mashour
Pharmacological Reviews October 1, 2019, 71 (4) 450-466; DOI: https://doi.org/10.1124/pr.118.016592
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  • Article
    • Abstract
    • I. Introduction
    • II. Basic Pharmacology and Physicochemical Properties of the Halogenated Ethers
    • III. Basic Overview of Voltage-Gated Sodium Channel Biology
    • IV. Molecular Interactions of Halogenated Ethers with Voltage-Gated Sodium Channels
    • V. Structural and Computational Studies Using Prokaryotic Voltage-Gated Sodium Channels
    • VI. Presynaptic Voltage-Gated Sodium Channel Inhibition Leads to Depressed Neurotransmission
    • VII. In Vivo Modulation of Halogenated Ether Anesthesia
    • VIII. Conclusion
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
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