Review ArticleReview Article
Open Access
Role of Voltage-Gated Sodium Channels in the Mechanism of Ether-Induced Unconsciousness
Nicholas Denomme, Jacob M. Hull and George A. Mashour
Lori L. Isom, ASSOCIATE EDITOR
Pharmacological Reviews October 2019, 71 (4) 450-466; DOI: https://doi.org/10.1124/pr.118.016592
Nicholas Denomme
Departments of Pharmacology (N.D.) and Anesthesiology (G.A.M.), Center for Consciousness Science (N.D., G.A.M.), and Neuroscience Graduate Program (J.M.H., G.A.M.), University of Michigan, Ann Arbor, Michigan
Jacob M. Hull
Departments of Pharmacology (N.D.) and Anesthesiology (G.A.M.), Center for Consciousness Science (N.D., G.A.M.), and Neuroscience Graduate Program (J.M.H., G.A.M.), University of Michigan, Ann Arbor, Michigan
George A. Mashour
Departments of Pharmacology (N.D.) and Anesthesiology (G.A.M.), Center for Consciousness Science (N.D., G.A.M.), and Neuroscience Graduate Program (J.M.H., G.A.M.), University of Michigan, Ann Arbor, Michigan
Lori L. Isom
Roles: ASSOCIATE EDITOR

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In this issue
Review ArticleReview Article
Sodium Channels and General Anesthesia
Nicholas Denomme, Jacob M. Hull and George A. Mashour
Pharmacological Reviews October 1, 2019, 71 (4) 450-466; DOI: https://doi.org/10.1124/pr.118.016592
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- Article
- Abstract
- I. Introduction
- II. Basic Pharmacology and Physicochemical Properties of the Halogenated Ethers
- III. Basic Overview of Voltage-Gated Sodium Channel Biology
- IV. Molecular Interactions of Halogenated Ethers with Voltage-Gated Sodium Channels
- V. Structural and Computational Studies Using Prokaryotic Voltage-Gated Sodium Channels
- VI. Presynaptic Voltage-Gated Sodium Channel Inhibition Leads to Depressed Neurotransmission
- VII. In Vivo Modulation of Halogenated Ether Anesthesia
- VIII. Conclusion
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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