Review ArticleReview Article
Beyond the Ligand: Extracellular and Transcellular G Protein–Coupled Receptor Complexes in Physiology and Pharmacology
Henry A. Dunn, Cesare Orlandi and Kirill A. Martemyanov
Eric L. Barker, ASSOCIATE EDITOR
Pharmacological Reviews October 2019, 71 (4) 503-519; DOI: https://doi.org/10.1124/pr.119.018044
Henry A. Dunn
Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida
Cesare Orlandi
Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida
Kirill A. Martemyanov
Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida
Eric L. Barker
Roles: ASSOCIATE EDITOR

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In this issue
Review ArticleReview Article
Extracellular and Transcellular GPCR Complexes
Henry A. Dunn, Cesare Orlandi and Kirill A. Martemyanov
Pharmacological Reviews October 1, 2019, 71 (4) 503-519; DOI: https://doi.org/10.1124/pr.119.018044
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- Article
- Visual Overview
- Abstract
- I. The Emerging Extracellular Dimension of G Protein–Coupled Receptor Modulation
- II. Group III Metabotropic Glutamate Receptors Are Classic Neurotransmitter Receptors Subject to Transsynaptic Control by Endogenous Allosteric Modulators
- III. Alternative Splicing Defines the Extracellular Interactome of γ-Aminobutyric Acid Receptors
- IV. Multimodal Assemblies Involving Adhesion G Protein–Coupled Receptor Subfamily Ls (Latrophilins) Modulate Axonal Attraction, Repulsion, and Synapse Formation
- V. Direct Interaction of Adhesion G Protein–Coupled Receptor Subfamily G1/6 (G Protein–Coupled Receptor 56/126) with Extracellular Matrix Proteins Regulates Adhesion G Protein–Coupled Receptor Activation Mechanisms
- VI. Bidirectional Transsynaptic Coordination of Signaling Involving Complexes Composed of Adhesion G Protein–Coupled Receptor B1-3 (Brain-Specific Angiogenesis Inhibitor 1-3)
- VII. Assembly of Transsynaptic Complexes with Orphan G Protein–Coupled Receptor 158/179 Facilitates Bidirectional Scaffolding of Intracellular Signaling Molecules
- VIII. Concluding Remarks
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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