ADGRL1 (LPHN1) | Contactin-6 | Cis | Role in neurite outgrowth and apoptosis | Zuko et al. (2016) |
ADGRL1 (LPHN1) | Teneurin-2 | Trans/soluble | Synaptogenic interaction. Purified teneurin-2 ectodomain induces Ca2+ release in presynaptic boutons of hippocampal neurons | Silva et al. (2011) |
ADGRL1 (LPHN1) | Teneurin-2 | Trans/soluble | Role in axonal attraction and fasciculation. Functional role in neuromuscular junction transmission | Vysokov et al. (2018) |
ADGRL1 (LPHN1) | Teneurin-2 | Trans/soluble | Interaction in trans alters cAMP accumulation in ADGRL1-expressing cells | Li et al. (2018) |
ADGRL1-3 (LPHN1-3) | Teneurin-2, teneurin-4 | Trans/soluble | Induces cellular aggregation and junction formation. Interruption of interaction decreases synaptic density in cultured neurons | Boucard et al. (2014) |
ADGRL1-3 (LPHN1-3) | FLRT3 | Trans | Interruption of interaction decreases synaptic density in cultured neurons | Boucard et al. (2014) |
ADGRL1 (LPHN1) | FLRT3 | Trans | Role in defining excitatory synapse density, afferent input strength, and dendritic spine number | O’Sullivan et al. (2012) |
ADGRL3 (LPHN3) | FLRT2 | Trans | Interaction facilitates adhesion in HeLa cells and repulsion in cortical neurons | Jackson et al. (2015) |
ADGRL1 (LPHN1) | FLRT2 | Trans | Complex with Unc5D inhibits cell adhesion | Jackson et al. (2016) |
ADGRL1 (LPHN1) | NRXN1 | Trans | ADGRL1 competes with neuroligin to form a transcellular adhesion complex with neurexin | Boucard et al. (2012) |
ADGRC3 (CELSR3) | Dystroglycan | Trans | Role in axon guidance | Lindenmaier et al. (2019) |
ADGRB3 (BAI3) | C1ql3 | Soluble | Ca2+-dependent interaction with TSRs in ADGRB3 ectodomain | Bolliger et al. (2011) |
ADGRB3 (BAI3) | C1ql1 | Soluble | Role in motor learning at climbing fiber-Purkinje cell synapses | Kakegawa et al. (2015) |
ADGRB3 (BAI3) | C1ql1 | Soluble | C1ql1’s modulation of Purkinje cell spinogenesis is ADGRB3 dependent | Sigoillot et al. (2015) |
ADGRB3 (BAI3) | C1ql4 | Soluble | C1ql4 interacts with ADGRB3 to suppress myoblast fusion | Hamoud et al. (2014) |
ADGRB3 (BAI3) | Stabilin-2 | Cis | Stabilin-2 interacts in cis to promote G protein activation via ADGRB3 and activate myoblast fusion | Hamoud et al. (2014) |
ADGRB1 (BAI1) | Neuroligin-1 | Cis | Role in spinogenesis, excitatory synaptogenesis, and presynaptic clustering of vGlut1 with neuroligin-neurexin transcomplex | Tu et al. (2018) |
ADGRB1 (BAI1) | Integrin αVβ5 | Trans | ADGRB1 ectodomain shows antiproliferative effects by blocking αVβ5 integrin | Koh et al. (2004) |
ADGRB1 (BAI1) | CD36 | Trans | ADGRB1 released ectodomain mediates antivascular effects by interacting with CD36 | Kaur et al. (2009) |
ADGRE5 (CD97) | CD55 | Trans | Role in cell adhesion | Hamann et al. (1996) |
ADGRE5 (CD97) | CD55 | Trans | Promotes receptor desensitization after ectodomain cleavage | Karpus et al. (2013) |
ADGRE5 (CD97) | CD90 | Trans | Role in leukocyte adhesion to activated endothelium during inflammatory processes | Wandel et al. (2012) |
ADGRE5 (CD97) | Integrin α5β1 | Trans | Interaction initiates endothelial cell invasion by inflammatory cells | Wang et al. (2005) |
ADGRG1 (GPR56) | Collagen III | Soluble | Promotes ADGRG1-dependent calcium signaling in pancreatic islet β cells | Olaniru et al. (2018) |
ADGRG1 (GPR56) | Collagen III | Soluble | Interaction activates Gα12/13-RhoA to control neuronal progenitor migration and corticogenesis | Luo et al. (2011, 2014) |
ADGRG6 (GPR126) | Collagen IV | Soluble | Collagen IV treatment of ADGRG6-expressing cells increases cAMP | Paavola et al. (2014) |
ADGRG6 (GPR126) | Laminin-211 | Soluble | Laminin-211 promotes myelination through ADGRG6 in vivo. Interaction reduces cAMP via ADGRG6 | Petersen et al. (2015) |
ADGRG6 (GPR126) | PrP | Soluble | PrP activates ADGRG6 to increase cAMP | Küffer et al. (2016) |
GPR179 | Pikachurin | Soluble | Pikachurin recruits GPR179-RGS complex to photoreceptor postsynaptic sites | Orlandi et al. (2018) |
GPR158 | Glypican4 | Trans | Role in presynaptic differentiation and defining input-specific synaptic properties at mossy fiber-CA3 synapses in hippocampus | Condomitti et al. (2018) |
mGluR7 | ELFN1 | Trans | Soluble ectodomain promotes constitutive activity | Stachniak et al. (2019) |
mGluR7 | ELFN1 | Trans | Role in synaptic targeting of mGluR7 | Tomioka et al. (2014) |
mGluR6 | ELFN1 | Trans | Role in promoting mGluR6 expression and synaptic targeting | Cao et al. (2015) |
mGluR4/6 | ELFN1 | Trans | Allosteric modulation of mGluR4/6 via G protein coupling mechanisms. Promotes constitutive activity | Dunn et al. (2018) |
GABABR1a | APP/sAPP | Soluble | Modulates GABABR1a axonal trafficking and signaling to decrease vesicle release probability | Dinamarca et al. (2019), Rice et al. (2019) |