Review ArticleReview Article
Harnessing Ion-Binding Sites for GPCR Pharmacology
Barbara Zarzycka, Saheem A. Zaidi, Bryan L. Roth and Vsevolod Katritch
Eric L. Barker, ASSOCIATE EDITOR
Pharmacological Reviews October 2019, 71 (4) 571-595; DOI: https://doi.org/10.1124/pr.119.017863
Barbara Zarzycka
Departments of Biological Sciences (B.Z., S.A.Z., V.K.) and Chemistry (V.K.), Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California; and Department of Pharmacology (B.L.R.) and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy (B.L.R.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Saheem A. Zaidi
Departments of Biological Sciences (B.Z., S.A.Z., V.K.) and Chemistry (V.K.), Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California; and Department of Pharmacology (B.L.R.) and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy (B.L.R.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Bryan L. Roth
Departments of Biological Sciences (B.Z., S.A.Z., V.K.) and Chemistry (V.K.), Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California; and Department of Pharmacology (B.L.R.) and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy (B.L.R.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Vsevolod Katritch
Departments of Biological Sciences (B.Z., S.A.Z., V.K.) and Chemistry (V.K.), Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, California; and Department of Pharmacology (B.L.R.) and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy (B.L.R.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Eric L. Barker
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
Harnessing Ion-Binding Sites for GPCR Pharmacology
Barbara Zarzycka, Saheem A. Zaidi, Bryan L. Roth and Vsevolod Katritch
Pharmacological Reviews October 1, 2019, 71 (4) 571-595; DOI: https://doi.org/10.1124/pr.119.017863
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- Article
- Abstract
- I. Historical Overview
- II. Structural Data for Conserved and Nonconserved Ion Binding Sites in G-Protein-Coupled Receptors
- III. Functional Role—Why is Sodium So Special for Class A G-Protein-Coupled Receptors?
- IV. Ion Binding Sites as Ligand Targets—New Approaches to Design Functional Properties
- V. Biophysical and Computational Approaches for Studying Allosteric Ions
- VI. Unanswered Questions and Future Perspectives
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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