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Open Access

G Protein–Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action

Stacy Gelhaus Wendell, Hao Fan and Cheng Zhang
Paul A. Insel, ASSOCIATE EDITOR
Pharmacological Reviews January 2020, 72 (1) 1-49; DOI: https://doi.org/10.1124/pr.118.016899
Stacy Gelhaus Wendell
Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania (S.G.W., C.Z.); Bioinformatics Institute, Agency for Science, Technology, and Research, Singapore (H.F.); and Department of Biological Sciences, National University of Singapore, and Center for Computational Biology, DUKE-NUS Medical School, Singapore (H.F.)
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Hao Fan
Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania (S.G.W., C.Z.); Bioinformatics Institute, Agency for Science, Technology, and Research, Singapore (H.F.); and Department of Biological Sciences, National University of Singapore, and Center for Computational Biology, DUKE-NUS Medical School, Singapore (H.F.)
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  • For correspondence: fanh@bii.a-star.edu.sg
Cheng Zhang
Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania (S.G.W., C.Z.); Bioinformatics Institute, Agency for Science, Technology, and Research, Singapore (H.F.); and Department of Biological Sciences, National University of Singapore, and Center for Computational Biology, DUKE-NUS Medical School, Singapore (H.F.)
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  • For correspondence: chengzh@pitt.edu
Paul A. Insel
Roles: ASSOCIATE EDITOR
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Article Information

vol. 72 no. 1 1-49
DOI 
https://doi.org/10.1124/pr.118.016899
PubMed 
31767622

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online November 25, 2019.

Copyright & Usage 
Copyright © 2019 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

Author Information

  1. Stacy Gelhaus Wendell,
  2. Hao Fan⇑, and
  3. Cheng Zhang⇑
  1. Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania (S.G.W., C.Z.); Bioinformatics Institute, Agency for Science, Technology, and Research, Singapore (H.F.); and Department of Biological Sciences, National University of Singapore, and Center for Computational Biology, DUKE-NUS Medical School, Singapore (H.F.)
  1. Address correspondence to:
    Dr. Hao Fan, Bioinformatics Institute, A*STAR, 30 Biopolis Street, Matrix #07-01, Singapore 138671. E-mail: fanh{at}bii.a-star.edu.sg or
  2. Dr. Cheng Zhang, Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, 203 Lothrop Street, Pittsburgh, PA 15261. E-mail: chengzh{at}pitt.edu
  1. Paul A. Insel, ASSOCIATE EDITOR
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Pharmacological Reviews: 72 (1)
Pharmacological Reviews
Vol. 72, Issue 1
1 Jan 2020
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Review ArticleReview Article

Pharmacology of GPCRs in Asthma Therapy and Drug Action

Stacy Gelhaus Wendell, Hao Fan and Cheng Zhang
Pharmacological Reviews January 1, 2020, 72 (1) 1-49; DOI: https://doi.org/10.1124/pr.118.016899

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Review ArticleReview Article

Pharmacology of GPCRs in Asthma Therapy and Drug Action

Stacy Gelhaus Wendell, Hao Fan and Cheng Zhang
Pharmacological Reviews January 1, 2020, 72 (1) 1-49; DOI: https://doi.org/10.1124/pr.118.016899
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  • Article
    • Abstract
    • I. Asthma and Asthma Therapy
    • II. β2-Adrenergic Receptor and β2-Agonists
    • III. Muscarinic Acetylcholine Receptors and Muscarinic Antagonists
    • IV. Cysteinyl Leukotriene Receptors and Leukotriene Antagonists
    • V. Potential G Protein–Coupled Receptor–Targeting Drugs for Asthma in Late-Stage Clinical Trials
    • VI. Future Perspectives
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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