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Review ArticleReview Article

High-dimensionality Data Analysis of Pharmacological Systems Associated with Complex Diseases

Jhana O. Hendrickx, Jaana van Gastel, Hanne Leysen, Bronwen Martin and Stuart Maudsley
Martin C. Michel, ASSOCIATE EDITOR
Pharmacological Reviews January 2020, 72 (1) 191-217; DOI: https://doi.org/10.1124/pr.119.017921
Jhana O. Hendrickx
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
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Jaana van Gastel
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
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Hanne Leysen
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
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Bronwen Martin
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
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Stuart Maudsley
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
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Martin C. Michel
Roles: ASSOCIATE EDITOR
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Article Information

vol. 72 no. 1 191-217
DOI 
https://doi.org/10.1124/pr.119.017921
PubMed 
31843941

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online December 16, 2019.

Copyright & Usage 
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jhana O. Hendrickx,
  2. Jaana van Gastel,
  3. Hanne Leysen,
  4. Bronwen Martin, and
  5. Stuart Maudsley
  1. Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
  1. Martin C. Michel, ASSOCIATE EDITOR
  1. Address correspondence to:
    Stuart Maudsley, Receptor Biology Laboratory, Department of Biomedical Sciences, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium. E-mail: stuart.maudsley{at}uantwerpen.be
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Pharmacological Reviews: 72 (1)
Pharmacological Reviews
Vol. 72, Issue 1
1 Jan 2020
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Review ArticleReview Article

Deconvoluting Complex Pharmacological Systems

Jhana O. Hendrickx, Jaana van Gastel, Hanne Leysen, Bronwen Martin and Stuart Maudsley
Pharmacological Reviews January 1, 2020, 72 (1) 191-217; DOI: https://doi.org/10.1124/pr.119.017921

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Review ArticleReview Article

Deconvoluting Complex Pharmacological Systems

Jhana O. Hendrickx, Jaana van Gastel, Hanne Leysen, Bronwen Martin and Stuart Maudsley
Pharmacological Reviews January 1, 2020, 72 (1) 191-217; DOI: https://doi.org/10.1124/pr.119.017921
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  • Article
    • Abstract
    • I. Introduction
    • II. High-dimensionality Data in Pharmacological Paradigms
    • III. Management of High-dimensionality Experimental Data
    • IV. Classic Informatic Interrogation and Combinatorial Integration
    • V. Metadata Extraction and Crowd-Sourced Curation and Investigation
    • VI. Latent Semantic Analysis-Based Data Interpretation
    • VII. Electronic Medical Data File Analytics
    • VIII. Graph Theory Implementation for Signaling Network Deconvolution
    • IX. Data Visualization and Topological Methods
    • X. Machine Learning and Pattern Recognition
    • XI. Conclusions
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
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