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Review ArticleReview Article

High-dimensionality Data Analysis of Pharmacological Systems Associated with Complex Diseases

Jhana O. Hendrickx, Jaana van Gastel, Hanne Leysen, Bronwen Martin and Stuart Maudsley
Martin C. Michel, ASSOCIATE EDITOR
Pharmacological Reviews January 2020, 72 (1) 191-217; DOI: https://doi.org/10.1124/pr.119.017921
Jhana O. Hendrickx
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
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Jaana van Gastel
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
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Hanne Leysen
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
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Bronwen Martin
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
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Stuart Maudsley
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
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Martin C. Michel
Roles: ASSOCIATE EDITOR
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Pharmacological Reviews: 72 (1)
Pharmacological Reviews
Vol. 72, Issue 1
1 Jan 2020
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Review ArticleReview Article

Deconvoluting Complex Pharmacological Systems

Jhana O. Hendrickx, Jaana van Gastel, Hanne Leysen, Bronwen Martin and Stuart Maudsley
Pharmacological Reviews January 1, 2020, 72 (1) 191-217; DOI: https://doi.org/10.1124/pr.119.017921

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Review ArticleReview Article

Deconvoluting Complex Pharmacological Systems

Jhana O. Hendrickx, Jaana van Gastel, Hanne Leysen, Bronwen Martin and Stuart Maudsley
Pharmacological Reviews January 1, 2020, 72 (1) 191-217; DOI: https://doi.org/10.1124/pr.119.017921
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  • Article
    • Abstract
    • I. Introduction
    • II. High-dimensionality Data in Pharmacological Paradigms
    • III. Management of High-dimensionality Experimental Data
    • IV. Classic Informatic Interrogation and Combinatorial Integration
    • V. Metadata Extraction and Crowd-Sourced Curation and Investigation
    • VI. Latent Semantic Analysis-Based Data Interpretation
    • VII. Electronic Medical Data File Analytics
    • VIII. Graph Theory Implementation for Signaling Network Deconvolution
    • IX. Data Visualization and Topological Methods
    • X. Machine Learning and Pattern Recognition
    • XI. Conclusions
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
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