Review ArticleReview Article
High-dimensionality Data Analysis of Pharmacological Systems Associated with Complex Diseases
Jhana O. Hendrickx, Jaana van Gastel, Hanne Leysen, Bronwen Martin and Stuart Maudsley
Martin C. Michel, ASSOCIATE EDITOR
Pharmacological Reviews January 2020, 72 (1) 191-217; DOI: https://doi.org/10.1124/pr.119.017921
Jhana O. Hendrickx
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
Jaana van Gastel
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
Hanne Leysen
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
Bronwen Martin
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
Stuart Maudsley
Receptor Biology Laboratory, Department of Biomedical Research (J.O.H., J.v.G., H.L., S.M.) and Faculty of Pharmacy, Biomedical and Veterinary Sciences (J.O.H., J.v.G., H.L., B.M., S.M.), University of Antwerp, Antwerp, Belgium
Martin C. Michel
Roles: ASSOCIATE EDITOR

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In this issue
Review ArticleReview Article
Deconvoluting Complex Pharmacological Systems
Jhana O. Hendrickx, Jaana van Gastel, Hanne Leysen, Bronwen Martin and Stuart Maudsley
Pharmacological Reviews January 1, 2020, 72 (1) 191-217; DOI: https://doi.org/10.1124/pr.119.017921
Jump to section
- Article
- Abstract
- I. Introduction
- II. High-dimensionality Data in Pharmacological Paradigms
- III. Management of High-dimensionality Experimental Data
- IV. Classic Informatic Interrogation and Combinatorial Integration
- V. Metadata Extraction and Crowd-Sourced Curation and Investigation
- VI. Latent Semantic Analysis-Based Data Interpretation
- VII. Electronic Medical Data File Analytics
- VIII. Graph Theory Implementation for Signaling Network Deconvolution
- IX. Data Visualization and Topological Methods
- X. Machine Learning and Pattern Recognition
- XI. Conclusions
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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