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Review ArticleReview Article

Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease

Melanie A. Felmlee, Robert S. Jones, Vivian Rodriguez-Cruz, Kristin E. Follman and Marilyn E. Morris
Lynette C. Daws, ASSOCIATE EDITOR
Pharmacological Reviews April 2020, 72 (2) 466-485; DOI: https://doi.org/10.1124/pr.119.018762
Melanie A. Felmlee
Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California (M.A.F.); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (R.S.J., V.R.-C., M.E.M.); and Certara Strategic Consulting, Certara USA, Princeton, New Jersey (K.E.F.)
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Robert S. Jones
Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California (M.A.F.); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (R.S.J., V.R.-C., M.E.M.); and Certara Strategic Consulting, Certara USA, Princeton, New Jersey (K.E.F.)
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Vivian Rodriguez-Cruz
Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California (M.A.F.); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (R.S.J., V.R.-C., M.E.M.); and Certara Strategic Consulting, Certara USA, Princeton, New Jersey (K.E.F.)
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Kristin E. Follman
Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California (M.A.F.); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (R.S.J., V.R.-C., M.E.M.); and Certara Strategic Consulting, Certara USA, Princeton, New Jersey (K.E.F.)
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Marilyn E. Morris
Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California (M.A.F.); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (R.S.J., V.R.-C., M.E.M.); and Certara Strategic Consulting, Certara USA, Princeton, New Jersey (K.E.F.)
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Lynette C. Daws
Roles: ASSOCIATE EDITOR
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Article Information

vol. 72 no. 2 466-485
DOI 
https://doi.org/10.1124/pr.119.018762
PubMed 
32144120

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online March 6, 2020.

Copyright & Usage 
Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Melanie A. Felmlee1,
  2. Robert S. Jones1,
  3. Vivian Rodriguez-Cruz,
  4. Kristin E. Follman, and
  5. Marilyn E. Morris
  1. Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California (M.A.F.); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York (R.S.J., V.R.-C., M.E.M.); and Certara Strategic Consulting, Certara USA, Princeton, New Jersey (K.E.F.)
  1. Lynette C. Daws, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. Marilyn E. Morris, Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, 445 Pharmacy Building, Buffalo, NY 14214-8033. E-mail: memorris{at}buffalo.edu
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Pharmacological Reviews: 72 (2)
Pharmacological Reviews
Vol. 72, Issue 2
1 Apr 2020
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Review ArticleReview Article

Monocarboxylate Transporters in Health and Disease

Melanie A. Felmlee, Robert S. Jones, Vivian Rodriguez-Cruz, Kristin E. Follman and Marilyn E. Morris
Pharmacological Reviews April 1, 2020, 72 (2) 466-485; DOI: https://doi.org/10.1124/pr.119.018762

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Review ArticleReview Article

Monocarboxylate Transporters in Health and Disease

Melanie A. Felmlee, Robert S. Jones, Vivian Rodriguez-Cruz, Kristin E. Follman and Marilyn E. Morris
Pharmacological Reviews April 1, 2020, 72 (2) 466-485; DOI: https://doi.org/10.1124/pr.119.018762
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  • Article
    • Abstract
    • I. Introduction
    • II. Structure and Function
    • III. Expression and Localization
    • IV. Substrates and Inhibitors
    • V. Regulation and Development
    • VI. Monocarboxylate Transporters in Health and Disease
    • VII. Findings from the Use of Genetically-Modified Mct Rodent Models
    • VIII. Conclusions and Future Studies
    • Authorship Contributions
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