Review ArticleReview Article
Open Access
Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
Uddalak Bharadwaj, Moses M. Kasembeli, Prema Robinson and David J. Tweardy
Richard D. Ye, ASSOCIATE EDITOR
Pharmacological Reviews April 2020, 72 (2) 486-526; DOI: https://doi.org/10.1124/pr.119.018440
Uddalak Bharadwaj
Department of Infectious Diseases, Infection Control & Employee Health, Division of Internal Medicine (U.B., M.M.K., P.R., D.J.T.), and Department of Molecular and Cellular Oncology (D.J.T.), University of Texas, MD Anderson Cancer Center, Houston, Texas
Moses M. Kasembeli
Department of Infectious Diseases, Infection Control & Employee Health, Division of Internal Medicine (U.B., M.M.K., P.R., D.J.T.), and Department of Molecular and Cellular Oncology (D.J.T.), University of Texas, MD Anderson Cancer Center, Houston, Texas
Prema Robinson
Department of Infectious Diseases, Infection Control & Employee Health, Division of Internal Medicine (U.B., M.M.K., P.R., D.J.T.), and Department of Molecular and Cellular Oncology (D.J.T.), University of Texas, MD Anderson Cancer Center, Houston, Texas
David J. Tweardy
Department of Infectious Diseases, Infection Control & Employee Health, Division of Internal Medicine (U.B., M.M.K., P.R., D.J.T.), and Department of Molecular and Cellular Oncology (D.J.T.), University of Texas, MD Anderson Cancer Center, Houston, Texas
Richard D. Ye
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
Targeting JAK/STAT3 Signaling
Uddalak Bharadwaj, Moses M. Kasembeli, Prema Robinson and David J. Tweardy
Pharmacological Reviews April 1, 2020, 72 (2) 486-526; DOI: https://doi.org/10.1124/pr.119.018440
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- Article
- Abstract
- I. Molecular and Cellular Biology of Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling
- II. Biologic Functions of Janus Kinase/Signal Transducer and Activator of Transcription 3 in Basal Conditions
- III. Functions of Janus Kinase/Signal Transducer and Activator of Transcription 3 in Stress Conditions
- IV. Targeting Aberrant Janus Kinase/Signal Transducer and Activator of Transcription 3 Activity in Inflammatory, Fibrotic, Metabolic, and Oncological Diseases
- V. Considerations for Future Development of Janus Kinase/Signal Transducer and Activator of Transcription 3 Inhibitors
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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