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Review ArticleReview Article

Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies

Catherine A. Christian, Doodipala Samba Reddy, Jamie Maguire and Patrick A. Forcelli
Lori L. Isom, ASSOCIATE EDITOR
Pharmacological Reviews October 2020, 72 (4) 767-800; DOI: https://doi.org/10.1124/pr.119.017392
Catherine A. Christian
Department of Molecular and Integrative Physiology, Neuroscience Program, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois (C.A.C.); Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, Texas (D.S.R.); Neuroscience Department, Tufts University School of Medicine, Boston, Massachusetts (J.M.); and Departments of Pharmacology and Physiology and Neuroscience, Georgetown University, Washington, D.C. (P.A.F.)
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Doodipala Samba Reddy
Department of Molecular and Integrative Physiology, Neuroscience Program, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois (C.A.C.); Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, Texas (D.S.R.); Neuroscience Department, Tufts University School of Medicine, Boston, Massachusetts (J.M.); and Departments of Pharmacology and Physiology and Neuroscience, Georgetown University, Washington, D.C. (P.A.F.)
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Jamie Maguire
Department of Molecular and Integrative Physiology, Neuroscience Program, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois (C.A.C.); Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, Texas (D.S.R.); Neuroscience Department, Tufts University School of Medicine, Boston, Massachusetts (J.M.); and Departments of Pharmacology and Physiology and Neuroscience, Georgetown University, Washington, D.C. (P.A.F.)
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Patrick A. Forcelli
Department of Molecular and Integrative Physiology, Neuroscience Program, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois (C.A.C.); Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, Texas (D.S.R.); Neuroscience Department, Tufts University School of Medicine, Boston, Massachusetts (J.M.); and Departments of Pharmacology and Physiology and Neuroscience, Georgetown University, Washington, D.C. (P.A.F.)
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Lori L. Isom
Roles: ASSOCIATE EDITOR
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Pharmacological Reviews: 72 (4)
Pharmacological Reviews
Vol. 72, Issue 4
1 Oct 2020
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Review ArticleReview Article

Sex Differences in Epilepsy and Comorbidities

Catherine A. Christian, Doodipala Samba Reddy, Jamie Maguire and Patrick A. Forcelli
Pharmacological Reviews October 1, 2020, 72 (4) 767-800; DOI: https://doi.org/10.1124/pr.119.017392

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Review ArticleReview Article

Sex Differences in Epilepsy and Comorbidities

Catherine A. Christian, Doodipala Samba Reddy, Jamie Maguire and Patrick A. Forcelli
Pharmacological Reviews October 1, 2020, 72 (4) 767-800; DOI: https://doi.org/10.1124/pr.119.017392
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  • Article
    • Abstract
    • I. Introduction to Epilepsy, Seizures, and the Importance of Investigating Sex Differences
    • II. Sex Differences in Epilepsies and Comorbidities: Clinical Conditions and Animal Models
    • III. Catamenial Epilepsy: Fluctuations in Seizure Occurrence across the Menstrual Cycle
    • IV. Potential Neurobiological Bases for Sex Differences in Seizure Susceptibility and Epilepsy
    • V. Considerations for Antiseizure Pharmacotherapies, Drug Screening, and Development
    • VI. Concluding Remarks and Future Directions
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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