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Open Access

Mutations in G Protein–Coupled Receptors: Mechanisms, Pathophysiology and Potential Therapeutic Approaches

Torsten Schöneberg and Ines Liebscher
Paul Insel, ASSOCIATE EDITOR
Pharmacological Reviews January 2021, 73 (1) 89-119; DOI: https://doi.org/10.1124/pharmrev.120.000011
Torsten Schöneberg
Rudolf Schönheimer Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, Leipzig, Germany
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Ines Liebscher
Rudolf Schönheimer Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, Leipzig, Germany
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Paul Insel
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Article Information

vol. 73 no. 1 89-119
DOI 
https://doi.org/10.1124/pharmrev.120.000011
PubMed 
33219147

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online November 20, 2020.

Copyright & Usage 
Copyright © 2020 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

Author Information

  1. Torsten Schöneberg and
  2. Ines Liebscher
  1. Rudolf Schönheimer Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, Leipzig, Germany
  1. Paul Insel, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. Torsten Schöneberg, Rudolf Schönheimer Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, Johannisallee 30, 04103 Leipzig, Germany. E-mail: schoberg{at}medizin.uni-leipzig.de
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Pharmacological Reviews: 73 (1)
Pharmacological Reviews
Vol. 73, Issue 1
1 Jan 2021
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Review ArticleReview Article

Inherited GPCR-Related Diseases

Torsten Schöneberg and Ines Liebscher
Pharmacological Reviews January 1, 2021, 73 (1) 89-119; DOI: https://doi.org/10.1124/pharmrev.120.000011

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Review ArticleReview Article

Inherited GPCR-Related Diseases

Torsten Schöneberg and Ines Liebscher
Pharmacological Reviews January 1, 2021, 73 (1) 89-119; DOI: https://doi.org/10.1124/pharmrev.120.000011
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  • Article
    • Abstract
    • I. Introduction
    • II. History
    • III. General Mechanisms of GPCR Pathologies
    • IV. Inactivating Mutations of GPCRs
    • V. Activating Mutations in GPCRs—GoF
    • VI. Other Causes of GPCR Dysfunctions
    • VII. Therapeutic Options and Approaches
    • VIII. Identification of Disease-Relevant GPCR Using Population Genetic Data
    • IX. Future Perspectives
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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