Review ArticleReview Article
Open Access
The Emerging Role of the Innate Immune Response in Idiosyncratic Drug Reactions
Samantha Christine Sernoskie, Alison Jee and Jack Paul Uetrecht
Eric Barker, ASSOCIATE EDITOR
Pharmacological Reviews July 2021, 73 (3) 861-896; DOI: https://doi.org/10.1124/pharmrev.120.000090
Samantha Christine Sernoskie
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy (S.C.S., J.P.U.), and Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (A.J., J.P.U.)
Alison Jee
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy (S.C.S., J.P.U.), and Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (A.J., J.P.U.)
Jack Paul Uetrecht
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy (S.C.S., J.P.U.), and Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (A.J., J.P.U.)
Eric Barker
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
The Innate Immune Response in Idiosyncratic Drug Reactions
Samantha Christine Sernoskie, Alison Jee and Jack Paul Uetrecht
Pharmacological Reviews July 1, 2021, 73 (3) 861-896; DOI: https://doi.org/10.1124/pharmrev.120.000090
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- Article
- Visual Overview
- Abstract
- I. Introduction
- II. Review of Types of Idiosyncratic Drug Reactions
- III. Innate Mechanisms Contributing to Adaptive Immune Activation
- IV. Support for Immune Activation Using Model Drugs
- V. Conclusions and Perspectives
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
- PDF + SI
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