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Review ArticleReview Article

Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential

Simon Mathien, Chloé Tesnière and Sylvain Meloche
Michael Gottesman, ASSOCIATE EDITOR
Pharmacological Reviews October 2021, 73 (4) 1434-1467; DOI: https://doi.org/10.1124/pharmrev.120.000170
Simon Mathien
Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada (S.Ma., C.T., S.Me.); and Molecular Biology Program, Faculty of Medicine (C.T., S.Me.) and Department of Pharmacology and Physiology (S.Me.), Université de Montréal, Montreal, Quebec, Canada
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Chloé Tesnière
Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada (S.Ma., C.T., S.Me.); and Molecular Biology Program, Faculty of Medicine (C.T., S.Me.) and Department of Pharmacology and Physiology (S.Me.), Université de Montréal, Montreal, Quebec, Canada
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Sylvain Meloche
Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada (S.Ma., C.T., S.Me.); and Molecular Biology Program, Faculty of Medicine (C.T., S.Me.) and Department of Pharmacology and Physiology (S.Me.), Université de Montréal, Montreal, Quebec, Canada
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Michael Gottesman
Roles: ASSOCIATE EDITOR
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Article Information

vol. 73 no. 4 1434-1467
DOI 
https://doi.org/10.1124/pharmrev.120.000170
PubMed 
34732541

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online January 21, 2022.

Copyright & Usage 
Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Simon Mathien,
  2. Chloé Tesnière, and
  3. Sylvain Meloche
  1. Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada (S.Ma., C.T., S.Me.); and Molecular Biology Program, Faculty of Medicine (C.T., S.Me.) and Department of Pharmacology and Physiology (S.Me.), Université de Montréal, Montreal, Quebec, Canada
  1. Michael Gottesman, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. Sylvain Meloche, Institute for Research in Immunology and Cancer 2950, Chemin de Polytechnique Montreal, QC H3C 3J7, Canada. E-mail: sylvain.meloche{at}umontreal.ca
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Pharmacological Reviews: 73 (4)
Pharmacological Reviews
Vol. 73, Issue 4
1 Oct 2021
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Review ArticleReview Article

Regulation of MAPK Stability

Simon Mathien, Chloé Tesnière and Sylvain Meloche
Pharmacological Reviews October 1, 2021, 73 (4) 1434-1467; DOI: https://doi.org/10.1124/pharmrev.120.000170

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Review ArticleReview Article

Regulation of MAPK Stability

Simon Mathien, Chloé Tesnière and Sylvain Meloche
Pharmacological Reviews October 1, 2021, 73 (4) 1434-1467; DOI: https://doi.org/10.1124/pharmrev.120.000170
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  • Article
    • Visual Overview
    • Abstract
    • I. Introduction
    • II. Classic Mitogen-Activated Protein Kinase Pathways
    • III. Atypical Mitogen-Activated Protein Kinase Pathways
    • IV. Targeting Mitogen-Activated Protein Kinase Stability as a New Pharmacological Strategy
    • V. Concluding Remarks
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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