Table of Contents

Review Articles

• Open Access

  Brain Cancer Drug Discovery: Clinical Trials, Drug Classes, Targets, and Combinatorial Therapies

  Aleksandr V. Sokolov, Samira A. Dostdar, Misty M. Attwood, Aleksandra A. Krasilnikova, Anastasia A. Ilina, Amina Sh. Nabieva, Anna A. Lisitsyna, Vladimir N. Chubarev, Vadim V. Tarasov and Helgi B. Schiöth

  Michael Gottesman, ASSOCIATE EDITOR

  Pharmacological Reviews October 2021, 73 (4) 1172-1203; DOI: https://doi.org/10.1124/pharmrev.121.000317
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  Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection

  Sheila K. Pirooznia, Liana S. Rosenthal, Valina L. Dawson and Ted M. Dawson

  Eric Barker, ASSOCIATE EDITOR

  Pharmacological Reviews October 2021, 73 (4) 1204-1268; DOI: https://doi.org/10.1124/pharmrev.120.000189
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  Open Access

  Analgesic Potential of Terpenes Derived from Cannabis sativa

  Erika Liktor-Busa, Attila Keresztes, Justin LaVigne, John M. Streicher and Tally M. Largent-Milnes

  Eric Barker, ASSOCIATE EDITOR

  Pharmacological Reviews October 2021, 73 (4) 1269-1297; DOI: https://doi.org/10.1124/pharmrev.120.000046
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  L-Type Calcium Channel Blockers: A Potential Novel Therapeutic Approach to Drug Dependence

  Hilary J. Little

  Stephen Alexander, ASSOCIATE EDITOR

  Pharmacological Reviews October 2021, 73 (4) 1298-1325; DOI: https://doi.org/10.1124/pharmrev.120.000245
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  Gαs–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling

  Dana J. Ramms, Francesco Raimondi, Nadia Arang, Friedrich W. Herberg, Susan S. Taylor and J. Silvio Gutkind

  Gunnar Schulte, ASSOCIATE EDITOR

  Pharmacological Reviews October 2021, 73 (4) 1326-1368; DOI: https://doi.org/10.1124/pharmrev.120.000269
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  Open Access

  Pharmacological Modulation of Immune Responses by Nutritional Components

  Marthe T. van Daal, Gert Folkerts, Johan Garssen and Saskia Braber

  Clive Page, ASSOCIATE EDITOR

  Pharmacological Reviews October 2021, 73 (4) 1369-1403; DOI: https://doi.org/10.1124/pharmrev.120.000063
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  Open Access

  Nonantimicrobial Actions of Macrolides: Overview and Perspectives for Future Development

  Jennifer A. Kricker, Clive P. Page, Fridrik Runar Gardarsson, Olafur Baldursson, Thorarinn Gudjonsson and Michael J. Parnham

  Eric Barker, ASSOCIATE EDITOR

  Pharmacological Reviews October 2021, 73 (4) 1404-1433; DOI: https://doi.org/10.1124/pharmrev.121.000300
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  Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential

  Simon Mathien, Chloé Tesnière and Sylvain Meloche

  Michael Gottesman, ASSOCIATE EDITOR

  Pharmacological Reviews October 2021, 73 (4) 1434-1467; DOI: https://doi.org/10.1124/pharmrev.120.000170
• Open Access

  Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

  Kasper B. Hansen, Lonnie P. Wollmuth, Derek Bowie, Hiro Furukawa, Frank S. Menniti, Alexander I. Sobolevsky, Geoffrey T. Swanson, Sharon A. Swanger, Ingo H. Greger, Terunaga Nakagawa, Chris J. McBain, Vasanthi Jayaraman, Chian-Ming Low, Mark L. Dell’Acqua, Jeffrey S. Diamond, Chad R. Camp, Riley E. Perszyk, Hongjie Yuan and Stephen F. Traynelis

  Eric Barker, ASSOCIATE EDITOR

  Pharmacological Reviews October 2021, 73 (4) 1469-1658; DOI: https://doi.org/10.1124/pharmrev.120.000131
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  Inhaled β2 Adrenergic Agonists and Other cAMP-Elevating Agents: Therapeutics for Alveolar Injury and Acute Respiratory Disease Syndrome?

  Krishna Sriram, Michael B. Insel and Paul A. Insel

  Clive Page, ASSOCIATE EDITOR

  Pharmacological Reviews October 2021, 73 (4) 1659-1697; DOI: https://doi.org/10.1124/pharmrev.121.000356
• Open Access

  Structure-Based Virtual Screening for Ligands of G Protein–Coupled Receptors: What Can Molecular Docking Do for You?

  Flavio Ballante, Albert J Kooistra, Stefanie Kampen, Chris de Graaf and Jens Carlsson

  Gunnar Schulte, ASSOCIATE EDITOR

  Pharmacological Reviews October 2021, 73 (4) 1698-1736; DOI: https://doi.org/10.1124/pharmrev.120.000246