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Open Access

Therapeutic Opportunities and Delivery Strategies for Brain Revascularization in Stroke, Neurodegeneration, and Aging

Idoia Gallego, Ilia Villate-Beitia, Laura Saenz-del-Burgo, Gustavo Puras and José Luis Pedraz
Eric Barker, ASSOCIATE EDITOR
Pharmacological Reviews April 2022, 74 (2) 439-461; DOI: https://doi.org/10.1124/pharmrev.121.000418
Idoia Gallego
NanoBioCel Research Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P); Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine, Institute of Health Carlos III, Madrid, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P.); and Bioaraba, NanoBioCel Research Group, Vitoria-Gasteiz, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P.)
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Ilia Villate-Beitia
NanoBioCel Research Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P); Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine, Institute of Health Carlos III, Madrid, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P.); and Bioaraba, NanoBioCel Research Group, Vitoria-Gasteiz, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P.)
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Laura Saenz-del-Burgo
NanoBioCel Research Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P); Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine, Institute of Health Carlos III, Madrid, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P.); and Bioaraba, NanoBioCel Research Group, Vitoria-Gasteiz, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P.)
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Gustavo Puras
NanoBioCel Research Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P); Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine, Institute of Health Carlos III, Madrid, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P.); and Bioaraba, NanoBioCel Research Group, Vitoria-Gasteiz, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P.)
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José Luis Pedraz
NanoBioCel Research Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P); Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine, Institute of Health Carlos III, Madrid, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P.); and Bioaraba, NanoBioCel Research Group, Vitoria-Gasteiz, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P.)
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Eric Barker
Roles: ASSOCIATE EDITOR
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Article Information

vol. 74 no. 2 439-461
DOI 
https://doi.org/10.1124/pharmrev.121.000418
PubMed 
35302047

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Received June 7, 2021
  • Revision received January 18, 2022
  • Accepted January 22, 2022
  • Published online March 17, 2022.

Copyright & Usage 
Copyright © 2022 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

Author Information

  1. Idoia Gallego,
  2. Ilia Villate-Beitia,
  3. Laura Saenz-del-Burgo,
  4. Gustavo Puras, and
  5. José Luis Pedraz
  1. NanoBioCel Research Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P); Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine, Institute of Health Carlos III, Madrid, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P.); and Bioaraba, NanoBioCel Research Group, Vitoria-Gasteiz, Spain (I.G., I.V.-B., L.S.-B., G.P., J.L.P.)
  1. Eric Barker, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. José Luis Pedraz, Paseo de la Universidad, 7, Vitoria-Gasteiz, 01006, Spain. E-mail: joseluis.pedraz{at}ehu.eus; or Dr. Gustavo Puras, Paseo de la Universidad, 7, Vitoria-Gasteiz, 01006, Spain. E-mail: gustavo.puras{at}ehu.eus
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OtherReview Article

Therapeutic Opportunities for Brain Revascularization

Idoia Gallego, Ilia Villate-Beitia, Laura Saenz-del-Burgo, Gustavo Puras and José Luis Pedraz
Pharmacological Reviews April 1, 2022, 74 (2) 439-461; DOI: https://doi.org/10.1124/pharmrev.121.000418

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OtherReview Article

Therapeutic Opportunities for Brain Revascularization

Idoia Gallego, Ilia Villate-Beitia, Laura Saenz-del-Burgo, Gustavo Puras and José Luis Pedraz
Pharmacological Reviews April 1, 2022, 74 (2) 439-461; DOI: https://doi.org/10.1124/pharmrev.121.000418
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  • Article
    • Visual Overview
    • Abstract
    • I. Introduction
    • II. Mechanisms Regulating Brain Microvasculature
    • III. Vascular Disorders in Brain CNS Diseases
    • IV. New Opportunities for Brain Revascularization
    • V. Administration Routes for Targeting Brain Revascularization
    • VI. Conclusions and Future Directions
    • Acknowledgments
    • Authorship Contributions
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