Table of Contents

Review Article

• Open Access

  Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting

  Hui Lin, Frank Geurts, Luise Hassler, Daniel Batlle, Katrina M. Mirabito Colafella, Kate M. Denton, Jia L. Zhuo, Xiao C. Li, Nirupama Ramkumar, Masahiro Koizumi, Taiji Matsusaka, Akira Nishiyama, Martin J. Hoogduijn, Ewout J. Hoorn and A.H. Jan Danser

  Rhian Touyz, ASSOCIATE EDITOR

  Pharmacological Reviews July 2022, 74 (3) 462-505; DOI: https://doi.org/10.1124/pharmrev.120.000236
• 

  Open Access

  Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials

  Maija Dambrova, Marina Makrecka-Kuka, Janis Kuka, Reinis Vilskersts, Didi Nordberg, Misty M. Attwood, Stefan Smesny, Zumrut Duygu Sen, An Chi Guo, Eponine Oler, Siyang Tian, Jiamin Zheng, David S. Wishart, Edgars Liepinsh and Helgi B. Schiöth

  Jukka Hakkola, ASSOCIATE EDITOR

  Pharmacological Reviews July 2022, 74 (3) 506-551; DOI: https://doi.org/10.1124/pharmrev.121.000408
• Open Access

  The Nitrogen Mustards

  Martin S. Highley, Bart Landuyt, Hans Prenen, Peter G. Harper and Ernst A. De Bruijn

  Michael Gottesman, ASSOCIATE EDITOR

  Pharmacological Reviews July 2022, 74 (3) 552-599; DOI: https://doi.org/10.1124/pharmrev.120.000121
• Open Access

  Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders

  Gregory Hook, Thomas Reinheckel, Junjun Ni, Zhou Wu, Mark Kindy, Christoph Peters and Vivian Hook

  Eric Barker, ASSOCIATE EDITOR

  Pharmacological Reviews July 2022, 74 (3) 600-629; DOI: https://doi.org/10.1124/pharmrev.121.000527
• Open Access

  Allosteric Modulators of Metabotropic Glutamate Receptors as Novel Therapeutics for Neuropsychiatric Disease

  Deborah J. Luessen and P. Jeffrey Conn

  Lynette Daws, ASSOCIATE EDITOR

  Pharmacological Reviews July 2022, 74 (3) 630-661; DOI: https://doi.org/10.1124/pharmrev.121.000540
• 

  You have access

  Mass Spectrometry Approaches Empowering Neuropeptide Discovery and Therapeutics

  Krishna D. B. Anapindi, Elena V. Romanova, James W. Checco and Jonathan V. Sweedler

  Vivian Hook, ASSOCIATE EDITOR

  Pharmacological Reviews July 2022, 74 (3) 662-679; DOI: https://doi.org/10.1124/pharmrev.121.000423
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  Open Access

  New Technologies Bloom Together for Bettering Cancer Drug Conjugates

  Yiming Jin, Shahab Edalatian Zakeri, Raman Bahal and Andrew J. Wiemer

  Eric Barker, ASSOCIATE EDITOR

  Pharmacological Reviews July 2022, 74 (3) 680-713; DOI: https://doi.org/10.1124/pharmrev.121.000499
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  Open Access

  Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology

  Luiz G.N. de Almeida, Hayley Thode, Yekta Eslambolchi, Sameeksha Chopra, Daniel Young, Sean Gill, Laurent Devel and Antoine Dufour

  Gunnar Schulte, ASSOCIATE EDITOR

  Pharmacological Reviews July 2022, 74 (3) 714-770; DOI: https://doi.org/10.1124/pharmrev.121.000349
• You have access

  Quantitative Proteomics in Translational Absorption, Distribution, Metabolism, and Excretion and Precision Medicine

  Deepak Ahire, Laken Kruger, Sheena Sharma, Vijaya Saradhi Mettu, Abdul Basit and Bhagwat Prasad

  Charles France, ASSOCIATE EDITOR

  Pharmacological Reviews July 2022, 74 (3) 771-798; DOI: https://doi.org/10.1124/pharmrev.121.000449
• You have access

  ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain

  Gennady G. Yegutkin and Detlev Boison

  Stephen Alexander, ASSOCIATE EDITOR

  Pharmacological Reviews July 2022, 74 (3) 799-824; DOI: https://doi.org/10.1124/pharmrev.121.000528
• You have access

  Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response

  Zhengnan Yuan, Ladie Kimberly De La Cruz, Xiaoxiao Yang and Binghe Wang

  Qiang Ma, ASSOCIATE EDITOR

  Pharmacological Reviews July 2022, 74 (3) 825-875; DOI: https://doi.org/10.1124/pharmrev.121.000564