Article Figures & Data
Figures
- Fig. 1
Peptides are generated from larger precursor proteins in multiple steps: pre-propeptide synthesis in endoplasmic reticulum, packaging into dense-core secretory vesicles in the Golgi apparatus with proteolytic processing in the vesicles, transport to release sites, and finally, the stimulus-dependent secretion of mature bioactive peptides.
- Fig. 2
The analytical framework for neuropeptide characterization highlighting the major steps of sample preparation, MS-based measurement, and informatics, which combine to provide an exceptional toolset for neuropeptide discovery.
- Fig. 3
PTM characterization via MS and their functional implications. MS is effective at discovering both common and unexpected chemical modifications to peptides; these modifications impact receptor binding and lifetime and, hence, need to be characterized to test a peptide’s function.
In this issue
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- Article
- Visual Overview
- Abstract
- I. Introduction: A Century of Neuropeptide/Hormone Discovery: Where Are We and Where Are We Going?
- II. What Are Neuropeptides and Peptide Hormones?
- III. Methods of Neuropeptide Discovery and Characterization
- IV. From Discovery to Function
- V. Unusual Routes to Peptide Formation and Function
- VI. The Rise of Biologics: Therapeutic Peptides
- VII. Conclusions
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters