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Open Access

Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology

Luiz G.N. de Almeida, Hayley Thode, Yekta Eslambolchi, Sameeksha Chopra, Daniel Young, Sean Gill, Laurent Devel and Antoine Dufour
Gunnar Schulte, ASSOCIATE EDITOR
Pharmacological Reviews July 2022, 74 (3) 714-770; DOI: https://doi.org/10.1124/pharmrev.121.000349
Luiz G.N. de Almeida
Departments of Physiology and Pharmacology and Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada (L.G.N.d.A., Y.E., S.C., D.Y., A.D.); Department of Physiology and Pharmacology, University of Western Ontario, London, Canada (S.G., H.T.); and Université Paris-Saclay, CEA, INRAE, Medicaments et Technologies pour la Santé, Gif-sur-Yvette, France (L.D.)
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Hayley Thode
Departments of Physiology and Pharmacology and Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada (L.G.N.d.A., Y.E., S.C., D.Y., A.D.); Department of Physiology and Pharmacology, University of Western Ontario, London, Canada (S.G., H.T.); and Université Paris-Saclay, CEA, INRAE, Medicaments et Technologies pour la Santé, Gif-sur-Yvette, France (L.D.)
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Yekta Eslambolchi
Departments of Physiology and Pharmacology and Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada (L.G.N.d.A., Y.E., S.C., D.Y., A.D.); Department of Physiology and Pharmacology, University of Western Ontario, London, Canada (S.G., H.T.); and Université Paris-Saclay, CEA, INRAE, Medicaments et Technologies pour la Santé, Gif-sur-Yvette, France (L.D.)
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Sameeksha Chopra
Departments of Physiology and Pharmacology and Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada (L.G.N.d.A., Y.E., S.C., D.Y., A.D.); Department of Physiology and Pharmacology, University of Western Ontario, London, Canada (S.G., H.T.); and Université Paris-Saclay, CEA, INRAE, Medicaments et Technologies pour la Santé, Gif-sur-Yvette, France (L.D.)
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Daniel Young
Departments of Physiology and Pharmacology and Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada (L.G.N.d.A., Y.E., S.C., D.Y., A.D.); Department of Physiology and Pharmacology, University of Western Ontario, London, Canada (S.G., H.T.); and Université Paris-Saclay, CEA, INRAE, Medicaments et Technologies pour la Santé, Gif-sur-Yvette, France (L.D.)
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Sean Gill
Departments of Physiology and Pharmacology and Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada (L.G.N.d.A., Y.E., S.C., D.Y., A.D.); Department of Physiology and Pharmacology, University of Western Ontario, London, Canada (S.G., H.T.); and Université Paris-Saclay, CEA, INRAE, Medicaments et Technologies pour la Santé, Gif-sur-Yvette, France (L.D.)
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Laurent Devel
Departments of Physiology and Pharmacology and Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada (L.G.N.d.A., Y.E., S.C., D.Y., A.D.); Department of Physiology and Pharmacology, University of Western Ontario, London, Canada (S.G., H.T.); and Université Paris-Saclay, CEA, INRAE, Medicaments et Technologies pour la Santé, Gif-sur-Yvette, France (L.D.)
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Antoine Dufour
Departments of Physiology and Pharmacology and Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada (L.G.N.d.A., Y.E., S.C., D.Y., A.D.); Department of Physiology and Pharmacology, University of Western Ontario, London, Canada (S.G., H.T.); and Université Paris-Saclay, CEA, INRAE, Medicaments et Technologies pour la Santé, Gif-sur-Yvette, France (L.D.)
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Gunnar Schulte
Roles: ASSOCIATE EDITOR
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Article Information

vol. 74 no. 3 714-770
DOI 
https://doi.org/10.1124/pharmrev.121.000349
PubMed 
35738680

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online September 30, 2022.

Copyright & Usage 
Copyright © 2022 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

Author Information

  1. Luiz G.N. de Almeida,
  2. Hayley Thode,
  3. Yekta Eslambolchi,
  4. Sameeksha Chopra,
  5. Daniel Young,
  6. Sean Gill,
  7. Laurent Devel, and
  8. Antoine Dufour
  1. Departments of Physiology and Pharmacology and Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada (L.G.N.d.A., Y.E., S.C., D.Y., A.D.); Department of Physiology and Pharmacology, University of Western Ontario, London, Canada (S.G., H.T.); and Université Paris-Saclay, CEA, INRAE, Medicaments et Technologies pour la Santé, Gif-sur-Yvette, France (L.D.)
  1. Gunnar Schulte, ASSOCIATE EDITOR
  1. Address correspondence to
    : Dr. Antoine Dufour, University of Calgary, 3330 Hospital Drive Northwest, Calgary, Alberta 2TN 1N4, Canada. E-mail: antoine.dufour{at}ucalgary.ca
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Pharmacological Reviews: 74 (3)
Pharmacological Reviews
Vol. 74, Issue 3
1 Jul 2022
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Review ArticleReview Article

Pharmacology of Matrix Metalloproteinases

Luiz G.N. de Almeida, Hayley Thode, Yekta Eslambolchi, Sameeksha Chopra, Daniel Young, Sean Gill, Laurent Devel and Antoine Dufour
Pharmacological Reviews July 1, 2022, 74 (3) 714-770; DOI: https://doi.org/10.1124/pharmrev.121.000349

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Review ArticleReview Article

Pharmacology of Matrix Metalloproteinases

Luiz G.N. de Almeida, Hayley Thode, Yekta Eslambolchi, Sameeksha Chopra, Daniel Young, Sean Gill, Laurent Devel and Antoine Dufour
Pharmacological Reviews July 1, 2022, 74 (3) 714-770; DOI: https://doi.org/10.1124/pharmrev.121.000349
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  • Article
    • Visual Overview
    • Abstract
    • I. Introduction
    • II. Matrix Metalloproteinases
    • III. Molecular Mechanisms to Physiologic Roles of Matrix Metalloproteinases
    • IV. Pathophysiology of Matrix Metalloproteinases
    • V. Pharmacological Inhibitors of Matrix Metalloproteinases
    • VI. Molecular Tools for Targeting Active MMPs
    • VII. Future Perspectives
    • VIII. Conclusions
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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