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Review ArticleReview Article

ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain

Gennady G. Yegutkin and Detlev Boison
Stephen Alexander, ASSOCIATE EDITOR
Pharmacological Reviews July 2022, 74 (3) 799-824; DOI: https://doi.org/10.1124/pharmrev.121.000528
Gennady G. Yegutkin
MediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland (G.G.Y.); Department of Neurosurgery, Robert Wood Johnson and New Jersey Medical Schools, Rutgers University, Piscataway, New Jersey (D.B.); and Rutgers Brain Health Institute, Piscataway, New Jersey (D.B.)
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Detlev Boison
MediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland (G.G.Y.); Department of Neurosurgery, Robert Wood Johnson and New Jersey Medical Schools, Rutgers University, Piscataway, New Jersey (D.B.); and Rutgers Brain Health Institute, Piscataway, New Jersey (D.B.)
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Stephen Alexander
Roles: ASSOCIATE EDITOR
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Article Information

vol. 74 no. 3 799-824
DOI 
https://doi.org/10.1124/pharmrev.121.000528
PubMed 
35738682

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online September 30, 2022.

Copyright & Usage 
Copyright © 2022 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Gennady G. Yegutkin and
  2. Detlev Boison
  1. MediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland (G.G.Y.); Department of Neurosurgery, Robert Wood Johnson and New Jersey Medical Schools, Rutgers University, Piscataway, New Jersey (D.B.); and Rutgers Brain Health Institute, Piscataway, New Jersey (D.B.)
  1. Stephen Alexander, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. Gennady G. Yegutkin, MediCity Research Laboratory, Faculty of Medicine, University of Turku, Tykistökatu 6A, FIN-20520, Finland. E-mail: gennady.yegutkin{at}utu.fi; or Dr. Detlev Boison, Department of Neurosurgery, Rutgers Robert Wood Johnson Medical School, 683 Hoes Lane West, Piscataway, NJ 08854. E-mail: detlev.boison{at}rutgers.edu
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Pharmacological Reviews: 74 (3)
Pharmacological Reviews
Vol. 74, Issue 3
1 Jul 2022
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Review ArticleReview Article

Adenosine in Cancer

Gennady G. Yegutkin and Detlev Boison
Pharmacological Reviews July 1, 2022, 74 (3) 799-824; DOI: https://doi.org/10.1124/pharmrev.121.000528

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Review ArticleReview Article

Adenosine in Cancer

Gennady G. Yegutkin and Detlev Boison
Pharmacological Reviews July 1, 2022, 74 (3) 799-824; DOI: https://doi.org/10.1124/pharmrev.121.000528
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  • Article
    • Abstract
    • I. Introduction
    • II. Overview of Cellular Purine Turnover
    • III. Major Enzymes and Enzyme Families Involved in Cellular Adenosine Metabolism
    • IV. Hallmarks of Cancer Cell Metabolism
    • V. Dysregulation of Adenosine Metabolism in Cancer
    • VI. Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain
    • VII. Current Advances and Challenges in Targeting ATP and Adenosine Metabolism in Cancer
    • VIII. Conclusions and Outlook
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
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