Review ArticleReview Article
ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain
Gennady G. Yegutkin and Detlev Boison
Stephen Alexander, ASSOCIATE EDITOR
Pharmacological Reviews July 2022, 74 (3) 799-824; DOI: https://doi.org/10.1124/pharmrev.121.000528
Gennady G. Yegutkin
MediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland (G.G.Y.); Department of Neurosurgery, Robert Wood Johnson and New Jersey Medical Schools, Rutgers University, Piscataway, New Jersey (D.B.); and Rutgers Brain Health Institute, Piscataway, New Jersey (D.B.)
Detlev Boison
MediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland (G.G.Y.); Department of Neurosurgery, Robert Wood Johnson and New Jersey Medical Schools, Rutgers University, Piscataway, New Jersey (D.B.); and Rutgers Brain Health Institute, Piscataway, New Jersey (D.B.)
Stephen Alexander
Roles: ASSOCIATE EDITOR

Submit a Response to This Article
Jump to comment:
No eLetters have been published for this article.
In this issue
Review ArticleReview Article
Adenosine in Cancer
Gennady G. Yegutkin and Detlev Boison
Pharmacological Reviews July 1, 2022, 74 (3) 799-824; DOI: https://doi.org/10.1124/pharmrev.121.000528
Jump to section
- Article
- Abstract
- I. Introduction
- II. Overview of Cellular Purine Turnover
- III. Major Enzymes and Enzyme Families Involved in Cellular Adenosine Metabolism
- IV. Hallmarks of Cancer Cell Metabolism
- V. Dysregulation of Adenosine Metabolism in Cancer
- VI. Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain
- VII. Current Advances and Challenges in Targeting ATP and Adenosine Metabolism in Cancer
- VIII. Conclusions and Outlook
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement