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Review ArticleReview Article

Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response

Zhengnan Yuan, Ladie Kimberly De La Cruz, Xiaoxiao Yang and Binghe Wang
Qiang Ma, ASSOCIATE EDITOR
Pharmacological Reviews July 2022, 74 (3) 825-875; DOI: https://doi.org/10.1124/pharmrev.121.000564
Zhengnan Yuan
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia
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Ladie Kimberly De La Cruz
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia
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Xiaoxiao Yang
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia
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Binghe Wang
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia
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Qiang Ma
Roles: ASSOCIATE EDITOR
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Article Information

vol. 74 no. 3 825-875
DOI 
https://doi.org/10.1124/pharmrev.121.000564
PubMed 
35738683

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online September 30, 2022.

Copyright & Usage 
Copyright © 2022 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Zhengnan Yuan1,
  2. Ladie Kimberly De La Cruz1,
  3. Xiaoxiao Yang, and
  4. Binghe Wang
  1. Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia
  1. Qiang Ma, ASSOCIATE EDITOR
  1. Address correspondence to:
    Xiaoxiao Yang, Department of Chemistry, Georgia State University, 145 Piedmont Avenue Southeast, Atlanta, GA 30303. E-mail: xyang20{at}gsu.edu; or Binghe Wang, Department of Chemistry, Georgia State University, 145 Piedmont Avenue Southeast, Atlanta, GA 30303. E-mail: wang{at}gsu.edu
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Pharmacological Reviews: 74 (3)
Pharmacological Reviews
Vol. 74, Issue 3
1 Jul 2022
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Review ArticleReview Article

Molecular Mechanisms of CO-Mediated Signaling

Zhengnan Yuan, Ladie Kimberly De La Cruz, Xiaoxiao Yang and Binghe Wang
Pharmacological Reviews July 1, 2022, 74 (3) 825-875; DOI: https://doi.org/10.1124/pharmrev.121.000564

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Review ArticleReview Article

Molecular Mechanisms of CO-Mediated Signaling

Zhengnan Yuan, Ladie Kimberly De La Cruz, Xiaoxiao Yang and Binghe Wang
Pharmacological Reviews July 1, 2022, 74 (3) 825-875; DOI: https://doi.org/10.1124/pharmrev.121.000564
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  • Article
    • Abstract
    • I. Introduction
    • II. General Considerations in Examining the Molecular Targets of CO
    • III. A Bird’s-Eye View of the CO Target Collection: Its Landscape and Topography
    • IV. Carbon Monoxide Binding to Hemoproteins Involved in Oxygen Transport and Storage
    • V. Carbon Monoxide Binding to Heme-Containing Enzymes
    • VI. Neuronal PAS Domain Protein 2: Intersection with the Circadian Clock
    • VII. CO and Ion Channels
    • VIII. CO and the Cytochrome C-Cardiolipin Complex
    • IX. Two Long-Standing Issues in the CO Field: Possible Explanations at the Molecular Level
    • X. Conclusions
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
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