Review ArticleReview Article
Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response
Zhengnan Yuan, Ladie Kimberly De La Cruz, Xiaoxiao Yang and Binghe Wang
Qiang Ma, ASSOCIATE EDITOR
Pharmacological Reviews July 2022, 74 (3) 825-875; DOI: https://doi.org/10.1124/pharmrev.121.000564
Zhengnan Yuan
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia
Ladie Kimberly De La Cruz
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia
Xiaoxiao Yang
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia
Binghe Wang
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia
Qiang Ma
Roles: ASSOCIATE EDITOR

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In this issue
Review ArticleReview Article
Molecular Mechanisms of CO-Mediated Signaling
Zhengnan Yuan, Ladie Kimberly De La Cruz, Xiaoxiao Yang and Binghe Wang
Pharmacological Reviews July 1, 2022, 74 (3) 825-875; DOI: https://doi.org/10.1124/pharmrev.121.000564
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- Article
- Abstract
- I. Introduction
- II. General Considerations in Examining the Molecular Targets of CO
- III. A Bird’s-Eye View of the CO Target Collection: Its Landscape and Topography
- IV. Carbon Monoxide Binding to Hemoproteins Involved in Oxygen Transport and Storage
- V. Carbon Monoxide Binding to Heme-Containing Enzymes
- VI. Neuronal PAS Domain Protein 2: Intersection with the Circadian Clock
- VII. CO and Ion Channels
- VIII. CO and the Cytochrome C-Cardiolipin Complex
- IX. Two Long-Standing Issues in the CO Field: Possible Explanations at the Molecular Level
- X. Conclusions
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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