Review ArticleReview Article
Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer
Al-Hassan M. Mustafa and Oliver H. Krämer
Lynette Daws, ASSOCIATE EDITOR
Pharmacological Reviews January 2023, 75 (1) 35-61; DOI: https://doi.org/10.1124/pharmrev.122.000612
Al-Hassan M. Mustafa
Department of Toxicology, University Medical Center, Mainz, Germany (A.-H.M.M., O.H.K.) and Department of Zoology, Faculty of Science, Aswan University, Aswan, Egypt (A.-H.M.M.)
Oliver H. Krämer
Department of Toxicology, University Medical Center, Mainz, Germany (A.-H.M.M., O.H.K.) and Department of Zoology, Faculty of Science, Aswan University, Aswan, Egypt (A.-H.M.M.)
Lynette Daws
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
Novel Strategies to Target Dysregulated JAKs
Al-Hassan M. Mustafa and Oliver H. Krämer
Pharmacological Reviews January 1, 2023, 75 (1) 35-61; DOI: https://doi.org/10.1124/pharmrev.122.000612
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- Article
- Visual Overview
- Abstract
- I. Introduction
- II. Relevance of Janus Kinases for Tumorigenesis
- III. Histone Deacetylases Are Valid Pharmacological Targets in Janus Kinase Mutant Tumor Cells
- IV. Chemically Coupled Multitargeting Drugs
- V. Targeting Aberrant Janus Kinase Signaling by Proteolysis Targeting Chimeras and Histone Deacetylase Inhibitors
- VI. Clinical Trials to Assess the Safety and Efficacy of Combined Pharmacological Targeting of Janus Kinases and Histone Deacetylases
- VII. Summary
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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