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Open Access
G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry
Hsin-Yung Yen, Ali Jazayeri and Carol V. Robinson
Gunnar Schulte, ASSOCIATE EDITOR
Pharmacological Reviews May 2023, 75 (3) 397-415; DOI: https://doi.org/10.1124/pharmrev.120.000237
Hsin-Yung Yen
Department of Chemistry (H.-Y.Y., C.V.R.) Kavli Institute for Nanoscience Discovery (C.V.R.), University of Oxford, Oxford, UK; OMass Pharmaceuticals Ltd., Oxford, UK (H.-Y.Y., A.J.); and Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan (H.-Y.Y.)
Ali Jazayeri
Department of Chemistry (H.-Y.Y., C.V.R.) Kavli Institute for Nanoscience Discovery (C.V.R.), University of Oxford, Oxford, UK; OMass Pharmaceuticals Ltd., Oxford, UK (H.-Y.Y., A.J.); and Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan (H.-Y.Y.)
Carol V. Robinson
Department of Chemistry (H.-Y.Y., C.V.R.) Kavli Institute for Nanoscience Discovery (C.V.R.), University of Oxford, Oxford, UK; OMass Pharmaceuticals Ltd., Oxford, UK (H.-Y.Y., A.J.); and Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan (H.-Y.Y.)
Gunnar Schulte
Roles: ASSOCIATE EDITOR

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In this issue
Review ArticleReview Article
GPCR Pharmacology Captured by Mass Spectrometry
Hsin-Yung Yen, Ali Jazayeri and Carol V. Robinson
Pharmacological Reviews May 1, 2023, 75 (3) 397-415; DOI: https://doi.org/10.1124/pharmrev.120.000237
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- Article
- Abstract
- I. The Challenges of G Protein-Coupled Receptor Pharmacology
- II. Structural Mass Spectrometry for the Study of Proteins and Their Interactions
- III. Ligand/Drug Binding of G Protein-Coupled Receptors and Links With Post-Translational Modification
- IV. Interrogation of Interactions Between Receptors and Transducers
- V. Identification of Endogenous Modulators of G Protein Coupling
- VI. Outlook and Conclusions
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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