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Review ArticleReview Article

Pharmacological Regulation of Endoplasmic Reticulum Structure and Calcium Dynamics: Importance for Neurodegenerative Diseases

Ilmari Parkkinen, Anna Their, Muhammad Yasir Asghar, Sreesha Sree, Eija Jokitalo and Mikko Airavaara
Jukka Hakkola, Associate Editor
Pharmacological Reviews September 2023, 75 (5) 959-978; DOI: https://doi.org/10.1124/pharmrev.122.000701
Ilmari Parkkinen
Neuroscience Center (I.P., A.T., M.A.), Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy (I.P., M.A.), Cell and Tissue Dynamics Research Program, Institute of Biotechnology, Helsinki Institute of Life Sciences (M.Y.A., S.S., E.J.), and Electron Microscopy Unit, Institute of Biotechnology, Helsinki Institute of Life Sciences (E.J.), University of Helsinki, Helsinki, Finland
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Anna Their
Neuroscience Center (I.P., A.T., M.A.), Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy (I.P., M.A.), Cell and Tissue Dynamics Research Program, Institute of Biotechnology, Helsinki Institute of Life Sciences (M.Y.A., S.S., E.J.), and Electron Microscopy Unit, Institute of Biotechnology, Helsinki Institute of Life Sciences (E.J.), University of Helsinki, Helsinki, Finland
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Muhammad Yasir Asghar
Neuroscience Center (I.P., A.T., M.A.), Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy (I.P., M.A.), Cell and Tissue Dynamics Research Program, Institute of Biotechnology, Helsinki Institute of Life Sciences (M.Y.A., S.S., E.J.), and Electron Microscopy Unit, Institute of Biotechnology, Helsinki Institute of Life Sciences (E.J.), University of Helsinki, Helsinki, Finland
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Sreesha Sree
Neuroscience Center (I.P., A.T., M.A.), Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy (I.P., M.A.), Cell and Tissue Dynamics Research Program, Institute of Biotechnology, Helsinki Institute of Life Sciences (M.Y.A., S.S., E.J.), and Electron Microscopy Unit, Institute of Biotechnology, Helsinki Institute of Life Sciences (E.J.), University of Helsinki, Helsinki, Finland
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Eija Jokitalo
Neuroscience Center (I.P., A.T., M.A.), Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy (I.P., M.A.), Cell and Tissue Dynamics Research Program, Institute of Biotechnology, Helsinki Institute of Life Sciences (M.Y.A., S.S., E.J.), and Electron Microscopy Unit, Institute of Biotechnology, Helsinki Institute of Life Sciences (E.J.), University of Helsinki, Helsinki, Finland
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Mikko Airavaara
Neuroscience Center (I.P., A.T., M.A.), Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy (I.P., M.A.), Cell and Tissue Dynamics Research Program, Institute of Biotechnology, Helsinki Institute of Life Sciences (M.Y.A., S.S., E.J.), and Electron Microscopy Unit, Institute of Biotechnology, Helsinki Institute of Life Sciences (E.J.), University of Helsinki, Helsinki, Finland
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Jukka Hakkola
Roles: Associate Editor
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Pharmacological Reviews: 75 (5)
Pharmacological Reviews
Vol. 75, Issue 5
1 Sep 2023
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Review ArticleReview Article

Endoplasmic Reticulum Pharmacology in Neurodegeneration

Ilmari Parkkinen, Anna Their, Muhammad Yasir Asghar, Sreesha Sree, Eija Jokitalo and Mikko Airavaara
Pharmacological Reviews September 1, 2023, 75 (5) 959-978; DOI: https://doi.org/10.1124/pharmrev.122.000701

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Review ArticleReview Article

Endoplasmic Reticulum Pharmacology in Neurodegeneration

Ilmari Parkkinen, Anna Their, Muhammad Yasir Asghar, Sreesha Sree, Eija Jokitalo and Mikko Airavaara
Pharmacological Reviews September 1, 2023, 75 (5) 959-978; DOI: https://doi.org/10.1124/pharmrev.122.000701
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  • Article
    • Visual Overview
    • Abstract
    • I. Endoplasmic Reticulum Morphology and Overview of Ca2+-Related Endoplasmic Reticulum Functions
    • II. Specified Functions of Endoplasmic Reticulum Calcium in Neurons and Regulatory Targets
    • III. Neuron-Specific Endoplasmic Reticulum Requirements
    • IV. Endoplasmic Reticulum Stress in Neurons
    • V. Endoplasmic Reticulum and Ca2+ Dynamics in Neurodegeneration
    • VI. Pharmacological Tools To Modulate Endoplasmic Reticulum Function
    • VII. Concluding Remarks
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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