Time to change: A systems pharmacology approach to disentangle mechanisms of drug-induced mitochondrial toxicity

Charlotte A. Hoogstraten; Jonathan J. Lyon; Jan A.M. Smeitink; Frans G.M. Russel; Tom J.J. Schirris

doi:10.1124/pharmrev.122.000568

Article Information

PHARMREV-AR-2022-000568

DOI

https://doi.org/10.1124/pharmrev.122.000568

PubMed

36627212

Published By

American Society for Pharmacology and Experimental Therapeutics

Print ISSN

0031-6997

Online ISSN

1521-0081

History

Published online January 10, 2023.

© 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited and is not used for commercial purposes.

Author Information

Charlotte A. Hoogstraten1,
Jonathan J. Lyon2,
Jan A.M. Smeitink3,
Frans G.M. Russel1,*, and
Tom J.J. Schirris1

¹Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences and Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Netherlands
²Investigative Preclinical Toxicity & GSK Mitochondrial Network Lead, GlaxoSmithKline, United Kingdom
³Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center and Khondrion BV, Netherlands

↵* Corresponding Author:
Frans G.M. Russel, Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences and Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Department of Pharmacology and Toxicology, P. O. Box 9101, Nijmegen, N/A, 6500 HB, Netherlands. E-mail: frans.russel{at}radboudumc.nl