OtherReview Article
Time to change: A systems pharmacology approach to disentangle mechanisms of drug-induced mitochondrial toxicity
Charlotte A. Hoogstraten, Jonathan J. Lyon, Jan A.M. Smeitink, Frans G.M. Russel and Tom J.J. Schirris
Pharmacological Reviews February 17, 2023, PHARMREV-AR-2022-000568; DOI: https://doi.org/10.1124/pharmrev.122.000568
Charlotte A. Hoogstraten
1Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences and Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Netherlands
Jonathan J. Lyon
2Investigative Preclinical Toxicity & GSK Mitochondrial Network Lead, GlaxoSmithKline, United Kingdom
Jan A.M. Smeitink
3Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center and Khondrion BV, Netherlands
Frans G.M. Russel
1Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences and Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Netherlands
Tom J.J. Schirris
1Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences and Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Netherlands

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OtherReview Article
Systems pharmacology in drug-induced mitochondrial toxicity
Charlotte A. Hoogstraten, Jonathan J. Lyon, Jan A.M. Smeitink, Frans G.M. Russel and Tom J.J. Schirris
Pharmacological Reviews February 17, 2023, PHARMREV-AR-2022-000568; DOI: https://doi.org/10.1124/pharmrev.122.000568
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