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OtherReview Article

Current and emerging pharmacological targets and treatments of urinary incontinence and related disorders

Martin C. Michel, Linda Cardozo, Christopher J. Chermansky, Francisco Cruz, Yasuhiko Igawa, Kyu-Sung Lee, Arun Sahai, Alan J Wein and Karl-Erik Andersson
Pharmacological Reviews March 14, 2023, PHARMREV-AR-2021-000523; DOI: https://doi.org/10.1124/pharmrev.121.000523
Martin C. Michel
1Pharmacology, Johannes Gutenberg University, Germany
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  • For correspondence: marmiche@uni-mainz.de
Linda Cardozo
2Urogynaecology, King's College Hospital, United Kingdom
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Christopher J. Chermansky
3University of Pittsburgh, United States
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Francisco Cruz
4Urology, University of Porto, Portugal
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Yasuhiko Igawa
5Urology, Nagano Prefectural Hospital, Japan
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Kyu-Sung Lee
6Urology, Sungkyunkwan University, Korea, Republic of
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Arun Sahai
7King's College London, United Kingdom
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Alan J Wein
8Urology, University of Pennsylvania, United States
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Karl-Erik Andersson
9Institute for Regenerative Medicine, Wake Forest University Medical School, United States
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Abstract

The overactive bladder syndrome with and without urinary incontinence and related conditions, signs, and disorders such as detrusor overactivity, neurogenic voiding dysfunction, underactive bladder, stress urinary incontinence, and nocturia are common in the general population and have a major impact on the quality of life of the affected patients and their partners. Based on the deliberations of the subcommittee on pharmacological treatments of the 7th International Consultation on Incontinence, we present a comprehensive review of established drug targets in the treatment of overactive bladder syndrome and the above-mentioned related conditions and the approved drugs used in its treatment. Investigational drug targets and compounds are also reviewed. We conclude that despite a range of available medical treatment options, a considerable medical need continues to exist. This is largely because the existing treatments are symptomatic and have limited efficacy and/or tolerability, which leads to poor long-term adherence.

Significance Statement Urinary incontinence and related disorders are prevalent in the general population. While many treatments have been approved, few patients stay on long-term treatment despite none of them being curative. This manuscript provides a comprehensive discussion of existing and emerging treatment options for various types of incontinence and related disorders.

  • adrenergic receptors
  • bladder
  • botulinum
  • Muscarinic cholinergic receptors
  • Copyright © 2023 American Society for Pharmacology and Experimental Therapeutics

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Pharmacological Reviews: 75 (2)
Pharmacological Reviews
Vol. 75, Issue 2
1 Mar 2023
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OtherReview Article

Current and emergent targets and treatments of urinary incontinence

Martin C. Michel, Linda Cardozo, Christopher J. Chermansky, Francisco Cruz, Yasuhiko Igawa, Kyu-Sung Lee, Arun Sahai, Alan J Wein and Karl-Erik Andersson
Pharmacological Reviews March 14, 2023, PHARMREV-AR-2021-000523; DOI: https://doi.org/10.1124/pharmrev.121.000523

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OtherReview Article

Current and emergent targets and treatments of urinary incontinence

Martin C. Michel, Linda Cardozo, Christopher J. Chermansky, Francisco Cruz, Yasuhiko Igawa, Kyu-Sung Lee, Arun Sahai, Alan J Wein and Karl-Erik Andersson
Pharmacological Reviews March 14, 2023, PHARMREV-AR-2021-000523; DOI: https://doi.org/10.1124/pharmrev.121.000523
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