Data Supplement

• Supplemental Appendix 1 -

  Supplemental Appendix S1. Search Strategy. 
  

• Supplemental Appendix 2 -

  Supplemental Appendix S2. List of excluded articles retrieved from Medline and Embase at full-text screening*.
  
  

• Supplemental Appendix 3 -

  Supplemental Appendix S3. Summary of adverse events reported at a rate of 10% and above, serious adverse events, and discontinuation rates by arm of completed phase 3 and phase 2 trials.
  

• Supplemental Appendix 4 -

  Supplemental Appendix S4. Risk of bias assessment of the included trials using the Cochrane tool 2019*.