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Goods and bads of endocannabinoid system as a therapeutic target: Lessons learned after 30 years
Mauro Maccarrone, Vincenzo Di Marzo, Juerg Gertsch, Uwe Grether, Allyn C. Howlett, Tian Hua, Alexandros Makriyannis, Daniele Piomelli, Natsuo Ueda and Mario van der Stelt

Pharmacological Reviews May 10, 2023, PHARMREV-AR-2022-000600; DOI: https://doi.org/10.1124/pharmrev.122.000600
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Paradoxes of cellular SUMOylation regulation: a role of biomolecular condensates?
Xiaodong Cheng, Wenli Yang, Wei Lin and Fang Mei

Pharmacological Reviews May 3, 2023, PHARMREV-AR-2022-000784; DOI: https://doi.org/10.1124/pharmrev.122.000784
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Pharmacological regulation of endoplasmic reticulum structure and calcium dynamics: importance for neurodegenerative diseases
Ilmari Parkkinen, Anna Their, Muhammad Yasir Asghar, Sreesha Sree, Eija Jokitalo and Mikko Airavaara

Pharmacological Reviews May 1, 2023, PHARMREV-AR-2022-000701; DOI: https://doi.org/10.1124/pharmrev.122.000701
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Sulfotransferase 2B1b, Sterol Sulfonation, and Disease
Ian Cook and Thomas S. Leyh
Stephen Alexander, ASSOCIATE EDITOR

Pharmacological Reviews May 2023, 75 (3) 521-531; DOI: https://doi.org/10.1124/pharmrev.122.000679
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Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity
Charlotte A. Hoogstraten, Jonathan J. Lyon, Jan A.M. Smeitink, Frans G.M. Russel and Tom J.J. Schirris
John Schuetz, ASSOCIATE EDITOR

Pharmacological Reviews May 2023, 75 (3) 463-486; DOI: https://doi.org/10.1124/pharmrev.122.000568
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Understanding the Neural Mechanisms of General Anesthesia from Interaction with Sleep–Wake State: A Decade of Discovery
Wei-Wei Bao, Shan Jiang, Wei-Min Qu, Wen-Xian Li, Chang-Hong Miao and Zhi-Li Huang
Lynette Daws, ASSOCIATE EDITOR

Pharmacological Reviews May 2023, 75 (3) 532-553; DOI: https://doi.org/10.1124/pharmrev.122.000717
Open Access
Turn On, Tune In, Turnover! Target Biology Impacts In Vivo Potency, Efficacy, and Clearance
Johan Gabrielsson and Stephan Hjorth
Paul Insel, ASSOCIATE EDITOR

Pharmacological Reviews May 2023, 75 (3) 416-462; DOI: https://doi.org/10.1124/pharmrev.121.000524
Open Access
Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction
Qiang Ma
John Schuetz, ASSOCIATE EDITOR

Pharmacological Reviews May 2023, 75 (3) 487-520; DOI: https://doi.org/10.1124/pharmrev.122.000629
Open Access
G Protein-Coupled Receptor Pharmacology—Insights from Mass Spectrometry
Hsin-Yung Yen, Ali Jazayeri and Carol V. Robinson
Gunnar Schulte, ASSOCIATE EDITOR

Pharmacological Reviews May 2023, 75 (3) 397-415; DOI: https://doi.org/10.1124/pharmrev.120.000237
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β-Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives
Jürgen Wess, Antwi-Boasiako Oteng, Osvaldo Rivera-Gonzalez, Eugenia V. Gurevich and Vsevolod V. Gurevich

Pharmacological Reviews April 7, 2023, PHARMREV-AR-2021-000302; DOI: https://doi.org/10.1124/pharmrev.121.000302

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