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Harnessing Ion-Binding Sites for GPCR Pharmacology
Barbara Zarzycka, Saheem A. Zaidi, Bryan L. Roth and Vsevolod Katritch
Eric L. Barker, ASSOCIATE EDITOR

Pharmacological Reviews October 2019, 71 (4) 571-595; DOI: https://doi.org/10.1124/pr.119.017863
Open Access
Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure
Lauren B. Arendse, A. H. Jan Danser, Marko Poglitsch, Rhian M. Touyz, John C. Burnett, Catherine Llorens-Cortes, Mario R. Ehlers and Edward D. Sturrock
Eric L. Barker, ASSOCIATE EDITOR

Pharmacological Reviews October 2019, 71 (4) 539-570; DOI: https://doi.org/10.1124/pr.118.017129
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Druggable Transcriptional Networks in the Human Neurogenic Epigenome
Gerald A. Higgins, Aaron M. Williams, Alex S. Ade, Hasan B. Alam and Brian D. Athey
Lori L. Isom, ASSOCIATE EDITOR

Pharmacological Reviews October 2019, 71 (4) 520-538; DOI: https://doi.org/10.1124/pr.119.017681
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Beyond the Ligand: Extracellular and Transcellular G Protein–Coupled Receptor Complexes in Physiology and Pharmacology
Henry A. Dunn, Cesare Orlandi and Kirill A. Martemyanov
Eric L. Barker, ASSOCIATE EDITOR

Pharmacological Reviews October 2019, 71 (4) 503-519; DOI: https://doi.org/10.1124/pr.119.018044
Open Access
International Union of Basic and Clinical Pharmacology. CVII. Structure and Pharmacology of the Apelin Receptor with a Recommendation that Elabela/Toddler Is a Second Endogenous Peptide Ligand
Cai Read, Duuamene Nyimanu, Thomas L. Williams, David J. Huggins, Petra Sulentic, Robyn G. C. Macrae, Peiran Yang, Robert C. Glen, Janet J. Maguire and Anthony P. Davenport
Eliot H. Ohlstein, ASSOCIATE EDITOR

Pharmacological Reviews October 2019, 71 (4) 467-502; DOI: https://doi.org/10.1124/pr.119.017533
Open Access
Role of Voltage-Gated Sodium Channels in the Mechanism of Ether-Induced Unconsciousness
Nicholas Denomme, Jacob M. Hull and George A. Mashour
Lori L. Isom, ASSOCIATE EDITOR

Pharmacological Reviews October 2019, 71 (4) 450-466; DOI: https://doi.org/10.1124/pr.118.016592
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Cognitive Effects of MDMA in Laboratory Animals: A Systematic Review Focusing on Dose
Madeline M. Pantoni and Stephan G. Anagnostaras
Timothy A. Esbenshade, ASSOCIATE EDITOR

Pharmacological Reviews July 2019, 71 (3) 413-449; DOI: https://doi.org/10.1124/pr.118.017087
Open Access
5-HT₃ Receptor Antagonists in Neurologic and Neuropsychiatric Disorders: The Iceberg Still Lies beneath the Surface
Gohar Fakhfouri, Reza Rahimian, Jonas Dyhrfjeld-Johnsen, Mohammad Reza Zirak and Jean-Martin Beaulieu
Jeffrey M. Witkin, ASSOCIATE EDITOR

Pharmacological Reviews July 2019, 71 (3) 383-412; DOI: https://doi.org/10.1124/pr.118.015487
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The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases
Luca Antonioli, Corrado Blandizzi, Pál Pacher and György Haskó
Clive Page, ASSOCIATE EDITOR

Pharmacological Reviews July 2019, 71 (3) 345-382; DOI: https://doi.org/10.1124/pr.117.014878
Open Access
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics
R. L. Carhart-Harris and K. J. Friston
Eric L. Barker, ASSOCIATE EDITOR

Pharmacological Reviews July 2019, 71 (3) 316-344; DOI: https://doi.org/10.1124/pr.118.017160

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