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Announcement
Emily E. Scott

Pharmacological Reviews October 2021, 73 (4) 1468; DOI: https://doi.org/10.1124/pharmrev.121.000494
Open Access
Brain Cancer Drug Discovery: Clinical Trials, Drug Classes, Targets, and Combinatorial Therapies
Aleksandr V. Sokolov, Samira A. Dostdar, Misty M. Attwood, Aleksandra A. Krasilnikova, Anastasia A. Ilina, Amina Sh. Nabieva, Anna A. Lisitsyna, Vladimir N. Chubarev, Vadim V. Tarasov and Helgi B. Schiöth
Michael Gottesman, ASSOCIATE EDITOR

Pharmacological Reviews October 2021, 73 (4) 1172-1203; DOI: https://doi.org/10.1124/pharmrev.121.000317
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Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential
Simon Mathien, Chloé Tesnière and Sylvain Meloche
Michael Gottesman, ASSOCIATE EDITOR

Pharmacological Reviews October 2021, 73 (4) 1434-1467; DOI: https://doi.org/10.1124/pharmrev.120.000170
Open Access
Nonantimicrobial Actions of Macrolides: Overview and Perspectives for Future Development
Jennifer A. Kricker, Clive P. Page, Fridrik Runar Gardarsson, Olafur Baldursson, Thorarinn Gudjonsson and Michael J. Parnham
Eric Barker, ASSOCIATE EDITOR

Pharmacological Reviews October 2021, 73 (4) 1404-1433; DOI: https://doi.org/10.1124/pharmrev.121.000300
Open Access
Analgesic Potential of Terpenes Derived from Cannabis sativa
Erika Liktor-Busa, Attila Keresztes, Justin LaVigne, John M. Streicher and Tally M. Largent-Milnes
Eric Barker, ASSOCIATE EDITOR

Pharmacological Reviews October 2021, 73 (4) 1269-1297; DOI: https://doi.org/10.1124/pharmrev.120.000046
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Inhaled β2 Adrenergic Agonists and Other cAMP-Elevating Agents: Therapeutics for Alveolar Injury and Acute Respiratory Disease Syndrome?
Krishna Sriram, Michael B. Insel and Paul A. Insel
Clive Page, ASSOCIATE EDITOR

Pharmacological Reviews October 2021, 73 (4) 1659-1697; DOI: https://doi.org/10.1124/pharmrev.121.000356
Open Access
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Kasper B. Hansen, Lonnie P. Wollmuth, Derek Bowie, Hiro Furukawa, Frank S. Menniti, Alexander I. Sobolevsky, Geoffrey T. Swanson, Sharon A. Swanger, Ingo H. Greger, Terunaga Nakagawa, Chris J. McBain, Vasanthi Jayaraman, Chian-Ming Low, Mark L. Dell’Acqua, Jeffrey S. Diamond, Chad R. Camp, Riley E. Perszyk, Hongjie Yuan and Stephen F. Traynelis
Eric Barker, ASSOCIATE EDITOR

Pharmacological Reviews October 2021, 73 (4) 1469-1658; DOI: https://doi.org/10.1124/pharmrev.120.000131
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L-Type Calcium Channel Blockers: A Potential Novel Therapeutic Approach to Drug Dependence
Hilary J. Little
Stephen Alexander, ASSOCIATE EDITOR

Pharmacological Reviews October 2021, 73 (4) 1298-1325; DOI: https://doi.org/10.1124/pharmrev.120.000245
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Gαs–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling
Dana J. Ramms, Francesco Raimondi, Nadia Arang, Friedrich W. Herberg, Susan S. Taylor and J. Silvio Gutkind
Gunnar Schulte, ASSOCIATE EDITOR

Pharmacological Reviews October 2021, 73 (4) 1326-1368; DOI: https://doi.org/10.1124/pharmrev.120.000269
Open Access
Structure-Based Virtual Screening for Ligands of G Protein–Coupled Receptors: What Can Molecular Docking Do for You?
Flavio Ballante, Albert J Kooistra, Stefanie Kampen, Chris de Graaf and Jens Carlsson
Gunnar Schulte, ASSOCIATE EDITOR

Pharmacological Reviews October 2021, 73 (4) 1698-1736; DOI: https://doi.org/10.1124/pharmrev.120.000246

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