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E1 Enzymes as Therapeutic Targets in Cancer
Samir H. Barghout and Aaron D. Schimmer
Eric Barker, ASSOCIATE EDITOR

Pharmacological Reviews January 2021, 73 (1) 1-58; DOI: https://doi.org/10.1124/pharmrev.120.000053
Open Access
International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E₂ Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions
Xavier Norel, Yukihiko Sugimoto, Gulsev Ozen, Heba Abdelazeem, Yasmine Amgoud, Amel Bouhadoun, Wesam Bassiouni, Marie Goepp, Salma Mani, Hasanga D. Manikpurage, Amira Senbel, Dan Longrois, Akos Heinemann, Chengcan Yao and Lucie H. Clapp
Eliot H. Ohlstein, ASSOCIATE EDITOR

Pharmacological Reviews October 2020, 72 (4) 910-968; DOI: https://doi.org/10.1124/pr.120.019331
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Development of Novel, Value-Based, Digital Endpoints for Clinical Trials: A Structured Approach Toward Fit-for-Purpose Validation
M. D. Kruizinga, F. E. Stuurman, V. Exadaktylos, R. J. Doll, D. T. Stephenson, G. J. Groeneveld, G. J. A. Driessen and A. F. Cohen
Martin Michel, ASSOCIATE EDITOR

Pharmacological Reviews October 2020, 72 (4) 899-909; DOI: https://doi.org/10.1124/pr.120.000028
Open Access
RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges
Ai-Ming Yu, Young Hee Choi and Mei-Juan Tu
RHIAN M. TOUYZ, ASSOCIATE EDITOR

Pharmacological Reviews October 2020, 72 (4) 862-898; DOI: https://doi.org/10.1124/pr.120.019554
Open Access
Is Oxytocin “Nature’s Medicine”?
C. Sue Carter, William M. Kenkel, Evan L. MacLean, Steven R. Wilson, Allison M. Perkeybile, Jason R. Yee, Craig F. Ferris, Hossein P. Nazarloo, Stephen W. Porges, John M. Davis, Jessica J. Connelly and Marcy A. Kingsbury
Robert Dantzer, ASSOCIATE EDITOR

Pharmacological Reviews October 2020, 72 (4) 829-861; DOI: https://doi.org/10.1124/pr.120.019398
Open Access
On the Clinical Pharmacology of Reactive Oxygen Species
Ana I. Casas, Cristian Nogales, Hermann A. M. Mucke, Alexandra Petraina, Antonio Cuadrado, Ana I. Rojo, Pietro Ghezzi, Vincent Jaquet, Fiona Augsburger, Francois Dufrasne, Jalal Soubhye, Soni Deshwal, Moises Di Sante, Nina Kaludercic, Fabio Di Lisa and Harald H. H. W. Schmidt
Rhian M. Touyz, ASSOCIATE EDITOR

Pharmacological Reviews October 2020, 72 (4) 801-828; DOI: https://doi.org/10.1124/pr.120.019422
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Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies
Catherine A. Christian, Doodipala Samba Reddy, Jamie Maguire and Patrick A. Forcelli
Lori L. Isom, ASSOCIATE EDITOR

Pharmacological Reviews October 2020, 72 (4) 767-800; DOI: https://doi.org/10.1124/pr.119.017392
Open Access
The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway
V. Kapil, R. S. Khambata, D. A. Jones, K. Rathod, C. Primus, G. Massimo, J. M. Fukuto and A. Ahluwalia
Christopher J. Garland, ASSOCIATE EDITOR

Pharmacological Reviews July 2020, 72 (3) 692-766; DOI: https://doi.org/10.1124/pr.120.019240
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Using Pharmacology to Squeeze the Life Out of Childhood Leukemia, and Potential Strategies to Achieve Breakthroughs in Medulloblastoma Treatment
Juwina Wijaya, Tomoka Gose and John D. Schuetz
Qiang Ma, ASSOCIATE EDITOR

Pharmacological Reviews July 2020, 72 (3) 668-691; DOI: https://doi.org/10.1124/pr.118.016824
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Strategies to Modulate MicroRNA Functions for the Treatment of Cancer or Organ Injury
Tae Jin Lee, Xiaoyi Yuan, Keith Kerr, Ji Young Yoo, Dong H. Kim, Balveen Kaur and Holger K. Eltzschig
Eric L. Barker, ASSOCIATE EDITOR

Pharmacological Reviews July 2020, 72 (3) 639-667; DOI: https://doi.org/10.1124/pr.119.019026

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